Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region
Gut-associated lymphoreticular tissues, such as Peyer's patches and cecal patches, are important inductive sites for mucosal immune responses. As such, gut-associated lymphoreticular tissues may have an epithelial barrier different from that of villous epithelium. In this study, we investigated...
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| Veröffentlicht in: | Laboratory investigation 2003-07, Vol.83 (7), p.1045-1053 |
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| creator | Tamagawa, Hiroshi Takahashi, Ichiro Furuse, Mikio Yoshitake-Kitano, Yuka Tsukita, Shoichiro Ito, Toshinori Matsuda, Hikaru Kiyono, Hiroshi |
| description | Gut-associated lymphoreticular tissues, such as Peyer's patches and cecal patches, are important inductive sites for mucosal immune responses. As such, gut-associated lymphoreticular tissues may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, and -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared with stronger expression on the crypt side of villous epithelial cells; and claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches correlated with the presence of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling)-positive apoptotic cells, and Peyer's patch-deficient mice exhibited expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression was preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE. |
| doi_str_mv | 10.1097/01.LAB.0000078741.55670.6E |
| format | Article |
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As such, gut-associated lymphoreticular tissues may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, and -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared with stronger expression on the crypt side of villous epithelial cells; and claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches correlated with the presence of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling)-positive apoptotic cells, and Peyer's patch-deficient mice exhibited expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression was preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE.</description><identifier>ISSN: 0023-6837</identifier><identifier>EISSN: 1530-0307</identifier><identifier>DOI: 10.1097/01.LAB.0000078741.55670.6E</identifier><identifier>PMID: 12861044</identifier><identifier>CODEN: LAINAW</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Animals ; Apoptosis ; Biological and medical sciences ; Cecum - cytology ; Cecum - metabolism ; Claudin-4 ; Enterocytes - cytology ; Enterocytes - metabolism ; Fluorescent Antibody Technique, Indirect ; Fundamental and applied biological sciences. Psychology ; In Situ Nick-End Labeling ; Intestine, Small - cytology ; Intestine, Small - metabolism ; Intestine. Mesentery ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Occludin ; Pathology ; Peyer's Patches - cytology ; Peyer's Patches - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Tight Junctions - metabolism ; Vertebrates: digestive system</subject><ispartof>Laboratory investigation, 2003-07, Vol.83 (7), p.1045-1053</ispartof><rights>2003 United States & Canadian Academy of Pathology</rights><rights>The United States and Canadian Academy of Pathology, Inc. 2003</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-c250b20ef13982a1d52a1f411946ca63958afb963a8e9a65b1c6d0d3df9dcff33</citedby><cites>FETCH-LOGICAL-c603t-c250b20ef13982a1d52a1f411946ca63958afb963a8e9a65b1c6d0d3df9dcff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15043051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12861044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamagawa, Hiroshi</creatorcontrib><creatorcontrib>Takahashi, Ichiro</creatorcontrib><creatorcontrib>Furuse, Mikio</creatorcontrib><creatorcontrib>Yoshitake-Kitano, Yuka</creatorcontrib><creatorcontrib>Tsukita, Shoichiro</creatorcontrib><creatorcontrib>Ito, Toshinori</creatorcontrib><creatorcontrib>Matsuda, Hikaru</creatorcontrib><creatorcontrib>Kiyono, Hiroshi</creatorcontrib><title>Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region</title><title>Laboratory investigation</title><addtitle>Lab Invest</addtitle><addtitle>Lab Invest</addtitle><description>Gut-associated lymphoreticular tissues, such as Peyer's patches and cecal patches, are important inductive sites for mucosal immune responses. As such, gut-associated lymphoreticular tissues may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, and -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared with stronger expression on the crypt side of villous epithelial cells; and claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches correlated with the presence of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling)-positive apoptotic cells, and Peyer's patch-deficient mice exhibited expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression was preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cecum - cytology</subject><subject>Cecum - metabolism</subject><subject>Claudin-4</subject><subject>Enterocytes - cytology</subject><subject>Enterocytes - metabolism</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Situ Nick-End Labeling</subject><subject>Intestine, Small - cytology</subject><subject>Intestine, Small - metabolism</subject><subject>Intestine. Mesentery</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Occludin</subject><subject>Pathology</subject><subject>Peyer's Patches - cytology</subject><subject>Peyer's Patches - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Tight Junctions - metabolism</subject><subject>Vertebrates: digestive system</subject><issn>0023-6837</issn><issn>1530-0307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkd9u0zAUxiMEYmXwCsiaBFylHMexk4yr0mWAVIkKwbXlOierpyTObAdtvA1virNWqsTVfOE_8u_7ztH5kuSCwpJCVXwEutysPi9hXkVZ5HTJuShgKepnyYJyBikwKJ4nC4CMpaJkxVnyyvtbAJrngr9MzmhWCgp5vkj-rvfKKR3QGR-M9sS2ZN2pqTEDqe9Hh94bO5D4urZdZ3SH6cp7q40K2JB6NGGPnZn6WbfFB3QfPNmqoPfoL8nWYYsOh2BURzZWq878UWH2O1VJc6ICiS5kNeL9_DHfr2yP5AfeRPZ18qJVncc3x_M8-XVd_1x_TTffv3xbrzapFsBCqjMOuwywpawqM0UbHrc2p7TKhVaCVbxU7a4STJVYKcF3VIsGGta0VaPblrHz5P3Bd3T2bkIfZG-8xq5TA9rJy4LlJc0KEcGL_8BbO7kh9iazDLKC00fo8gBpZ72Pc5CjM71yD5KCnFOUQGVMUZ5SlI8pSlFH8dtjhWnXY3OSHmOLwLsjoHycauvUoI0_cRxyBpxG7tOB8_FruEF3avVJbVwd1BjH_ttEtdcGB42NcaiDbKx5is0_ZIfN5w</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Tamagawa, Hiroshi</creator><creator>Takahashi, Ichiro</creator><creator>Furuse, Mikio</creator><creator>Yoshitake-Kitano, Yuka</creator><creator>Tsukita, Shoichiro</creator><creator>Ito, Toshinori</creator><creator>Matsuda, Hikaru</creator><creator>Kiyono, Hiroshi</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region</title><author>Tamagawa, Hiroshi ; Takahashi, Ichiro ; Furuse, Mikio ; Yoshitake-Kitano, Yuka ; Tsukita, Shoichiro ; Ito, Toshinori ; Matsuda, Hikaru ; Kiyono, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-c250b20ef13982a1d52a1f411946ca63958afb963a8e9a65b1c6d0d3df9dcff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cecum - cytology</topic><topic>Cecum - metabolism</topic><topic>Claudin-4</topic><topic>Enterocytes - cytology</topic><topic>Enterocytes - metabolism</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Situ Nick-End Labeling</topic><topic>Intestine, Small - cytology</topic><topic>Intestine, Small - metabolism</topic><topic>Intestine. 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Academic</collection><jtitle>Laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamagawa, Hiroshi</au><au>Takahashi, Ichiro</au><au>Furuse, Mikio</au><au>Yoshitake-Kitano, Yuka</au><au>Tsukita, Shoichiro</au><au>Ito, Toshinori</au><au>Matsuda, Hikaru</au><au>Kiyono, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region</atitle><jtitle>Laboratory investigation</jtitle><stitle>Lab Invest</stitle><addtitle>Lab Invest</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>83</volume><issue>7</issue><spage>1045</spage><epage>1053</epage><pages>1045-1053</pages><issn>0023-6837</issn><eissn>1530-0307</eissn><coden>LAINAW</coden><abstract>Gut-associated lymphoreticular tissues, such as Peyer's patches and cecal patches, are important inductive sites for mucosal immune responses. As such, gut-associated lymphoreticular tissues may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, and -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared with stronger expression on the crypt side of villous epithelial cells; and claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches correlated with the presence of TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling)-positive apoptotic cells, and Peyer's patch-deficient mice exhibited expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression was preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>12861044</pmid><doi>10.1097/01.LAB.0000078741.55670.6E</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Biological and medical sciences Cecum - cytology Cecum - metabolism Claudin-4 Enterocytes - cytology Enterocytes - metabolism Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology In Situ Nick-End Labeling Intestine, Small - cytology Intestine, Small - metabolism Intestine. Mesentery Laboratory Medicine Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Occludin Pathology Peyer's Patches - cytology Peyer's Patches - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tight Junctions - metabolism Vertebrates: digestive system |
| title | Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region |
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