Gene Array Analysis of Bone Morphogenetic Protein Type I Receptor‐Induced Osteoblast Differentiation

The genomic response to BMP was investigated by ectopic expression of activated BMP type I receptors in C2C12 myoblast using cDNA microarrays. Novel BMP receptor target genes with possible roles in inhibition of myoblast differentiation and stimulation of osteoblast differentiation were identified....

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Veröffentlicht in:	Journal of bone and mineral research 2003-07, Vol.18 (7), p.1177-1185
Hauptverfasser:	Korchynskyi, Olexander, Dechering, Koen J, Sijbers, Anneke M, Olijve, Wiebe, Ten Dijke, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Bone Morphogenetic Protein Receptors, Type I bone morphogenetic proteins Cell Differentiation Cell Line Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Developmental Mice microarray osteoblast Osteoblasts - cytology Osteoblasts - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism signal transduction Skeleton and joints Smad Transcription, Genetic Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
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