The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins
Summary The growing pig is an established model animal for humans to determine protein digestibility to the end of the small intestine. An ileal amino acid digestibility assay based on the laboratory rat offers an alternative. True ileal amino acid digestibility in high quality refined protein sourc...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2003-08, Vol.87 (7-8), p.292-300 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Rutherfurd, S. M. Moughan, P. J. |
| description | Summary
The growing pig is an established model animal for humans to determine protein digestibility to the end of the small intestine. An ileal amino acid digestibility assay based on the laboratory rat offers an alternative. True ileal amino acid digestibility in high quality refined protein sources was determined and compared between the laboratory rat and the growing pig. Both species of animals were fed their daily ration in nine separate meals. Ileal digesta were collected at slaughter and chromic oxide was used as an indigestible marker. For several of the amino acids examined, there were no significant (p |
| doi_str_mv | 10.1046/j.1439-0396.2003.00438.x |
| format | Article |
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The growing pig is an established model animal for humans to determine protein digestibility to the end of the small intestine. An ileal amino acid digestibility assay based on the laboratory rat offers an alternative. True ileal amino acid digestibility in high quality refined protein sources was determined and compared between the laboratory rat and the growing pig. Both species of animals were fed their daily ration in nine separate meals. Ileal digesta were collected at slaughter and chromic oxide was used as an indigestible marker. For several of the amino acids examined, there were no significant (p < 0.05) differences between the two species for true ileal amino acid digestibility, but for aspartic acid, serine, cysteine, methionine, tyrosine, phenylalanine and histidine, significant (p < 0.05) interspecies differences were found. The overall average amino acid digestibility, for all amino acids and all diets, was 95.8% for the pig and 96.1% for the rat. Cysteine digestibility was highly variable between individual animals fed the same diet. The extent of amino acid digestion and absorption appears to be broadly similar across the two species, but some important differences in digestibility were recorded.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1046/j.1439-0396.2003.00438.x</identifier><identifier>PMID: 12864909</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Amino Acids - metabolism ; Animal Feed ; Animals ; Chromium Compounds ; Dietary Proteins - administration & dosage ; Dietary Proteins - metabolism ; Digestion ; Gastrointestinal Contents - chemistry ; Ileum - metabolism ; Male ; Milk Proteins - metabolism ; Models, Animal ; Rats - growth & development ; Rats - metabolism ; Rats, Sprague-Dawley ; Soybean Proteins - metabolism ; Species Specificity ; Swine - growth & development ; Swine - metabolism</subject><ispartof>Journal of animal physiology and animal nutrition, 2003-08, Vol.87 (7-8), p.292-300</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4688-a3e361feed98057ad77949618856bda14b0ea35ecc19e11a3ceacf6c61757da03</citedby><cites>FETCH-LOGICAL-c4688-a3e361feed98057ad77949618856bda14b0ea35ecc19e11a3ceacf6c61757da03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1439-0396.2003.00438.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1439-0396.2003.00438.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12864909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rutherfurd, S. M.</creatorcontrib><creatorcontrib>Moughan, P. J.</creatorcontrib><title>The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>Summary
The growing pig is an established model animal for humans to determine protein digestibility to the end of the small intestine. An ileal amino acid digestibility assay based on the laboratory rat offers an alternative. True ileal amino acid digestibility in high quality refined protein sources was determined and compared between the laboratory rat and the growing pig. Both species of animals were fed their daily ration in nine separate meals. Ileal digesta were collected at slaughter and chromic oxide was used as an indigestible marker. For several of the amino acids examined, there were no significant (p < 0.05) differences between the two species for true ileal amino acid digestibility, but for aspartic acid, serine, cysteine, methionine, tyrosine, phenylalanine and histidine, significant (p < 0.05) interspecies differences were found. The overall average amino acid digestibility, for all amino acids and all diets, was 95.8% for the pig and 96.1% for the rat. Cysteine digestibility was highly variable between individual animals fed the same diet. The extent of amino acid digestion and absorption appears to be broadly similar across the two species, but some important differences in digestibility were recorded.</description><subject>Amino Acids - metabolism</subject><subject>Animal Feed</subject><subject>Animals</subject><subject>Chromium Compounds</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Proteins - metabolism</subject><subject>Digestion</subject><subject>Gastrointestinal Contents - chemistry</subject><subject>Ileum - metabolism</subject><subject>Male</subject><subject>Milk Proteins - metabolism</subject><subject>Models, Animal</subject><subject>Rats - growth & development</subject><subject>Rats - metabolism</subject><subject>Rats, Sprague-Dawley</subject><subject>Soybean Proteins - metabolism</subject><subject>Species Specificity</subject><subject>Swine - growth & development</subject><subject>Swine - metabolism</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9PGzEQxS1UBCntV0A-9bZbO_Z61xIXioC2ilIOIKperIk9Gxz2T7A3Ivn29TYRXHuyPfPem_GPEMpZzplUX1c5l0JnTGiVTxkTOWNSVPn2iEzeGh_IhGnBs2kqnJKPMa4Y42XB1Ak55dNKSc30hGzun5AGGChECrTtHTYUOt9CQ-s-0CF1l6F_9d2Srv2S-o46HDC0vhtLvsEkhPTqKVjvqPNLjINf-MYPu1Ed-x2kQEdb3zzTdegH9F38RI5raCJ-Ppxn5OHm-v7qezb7dfvj6nKWWamqKgOBQvEa0emKFSW4stRSK15VhVo44HLBEESB1nKNnIOwCLZWVqV_lg6YOCNf9rlp8MsmbWZaHy02DXTYb6IphUzBU52E1V5oQx9jwNqsQ4IQdoYzMyI3KzOSNSNZMyI3_5CbbbKeH2ZsFi26d-OBcRJc7AWvCdfuv4PNz7t5uiR7trf7OOD2zQ7h2ahSlIV5nN-aP3MtZ99-P5q5-AugI6AR</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Rutherfurd, S. M.</creator><creator>Moughan, P. J.</creator><general>Blackwell Verlag GmbH</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins</title><author>Rutherfurd, S. M. ; Moughan, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4688-a3e361feed98057ad77949618856bda14b0ea35ecc19e11a3ceacf6c61757da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acids - metabolism</topic><topic>Animal Feed</topic><topic>Animals</topic><topic>Chromium Compounds</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Proteins - metabolism</topic><topic>Digestion</topic><topic>Gastrointestinal Contents - chemistry</topic><topic>Ileum - metabolism</topic><topic>Male</topic><topic>Milk Proteins - metabolism</topic><topic>Models, Animal</topic><topic>Rats - growth & development</topic><topic>Rats - metabolism</topic><topic>Rats, Sprague-Dawley</topic><topic>Soybean Proteins - metabolism</topic><topic>Species Specificity</topic><topic>Swine - growth & development</topic><topic>Swine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rutherfurd, S. M.</creatorcontrib><creatorcontrib>Moughan, P. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rutherfurd, S. M.</au><au>Moughan, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2003-08</date><risdate>2003</risdate><volume>87</volume><issue>7-8</issue><spage>292</spage><epage>300</epage><pages>292-300</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>Summary
The growing pig is an established model animal for humans to determine protein digestibility to the end of the small intestine. An ileal amino acid digestibility assay based on the laboratory rat offers an alternative. True ileal amino acid digestibility in high quality refined protein sources was determined and compared between the laboratory rat and the growing pig. Both species of animals were fed their daily ration in nine separate meals. Ileal digesta were collected at slaughter and chromic oxide was used as an indigestible marker. For several of the amino acids examined, there were no significant (p < 0.05) differences between the two species for true ileal amino acid digestibility, but for aspartic acid, serine, cysteine, methionine, tyrosine, phenylalanine and histidine, significant (p < 0.05) interspecies differences were found. The overall average amino acid digestibility, for all amino acids and all diets, was 95.8% for the pig and 96.1% for the rat. Cysteine digestibility was highly variable between individual animals fed the same diet. The extent of amino acid digestion and absorption appears to be broadly similar across the two species, but some important differences in digestibility were recorded.</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>12864909</pmid><doi>10.1046/j.1439-0396.2003.00438.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of animal physiology and animal nutrition, 2003-08, Vol.87 (7-8), p.292-300 |
| issn | 0931-2439 1439-0396 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Amino Acids - metabolism Animal Feed Animals Chromium Compounds Dietary Proteins - administration & dosage Dietary Proteins - metabolism Digestion Gastrointestinal Contents - chemistry Ileum - metabolism Male Milk Proteins - metabolism Models, Animal Rats - growth & development Rats - metabolism Rats, Sprague-Dawley Soybean Proteins - metabolism Species Specificity Swine - growth & development Swine - metabolism |
| title | The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins |
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