Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model

Gain-of-function mutations in the RET proto-oncogene resulting in a constitutively active receptor tyrosine kinase have been identified as responsible for three subtypes of multiple endocrine neoplasia type 2 (MEN-2) and the development of sporadic medullary and papillary thyroid carcinoma. An impor...

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