The Extended Interactions and Gla Domain of Blood Coagulation Factor Xa

The serine protease factor Xa (FXa) is inhibited by ecotin with picomolar affinity. The structure of the tetrameric complex of ecotin variant M84R (M84R) with FXa has been determined to 2.8 Å. Substrate directed induced fit of the binding interactions at the S2 and S4 pockets modulates the discrimin...

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Veröffentlicht in:	Biochemistry (Easton) 2003-07, Vol.42 (26), p.7959-7966
Hauptverfasser:	Wang, Stephanie X, Hur, Eugene, Sousa, Carolyn A, Brinen, Linda, Slivka, Eric J, Fletterick, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Carboxyglutamic Acid - chemistry Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Crystallography, X-Ray Escherichia coli Escherichia coli Proteins Factor Xa - chemistry Factor Xa - metabolism Humans Magnesium - metabolism Models, Molecular Peptide Fragments - chemistry Periplasmic Proteins Protein Conformation Protein Structure, Tertiary Sequence Alignment Serine Endopeptidases - chemistry Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - metabolism
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