A novel derivatization method for peptides to increase sensitivity and backbone fragmentation in liquid secondary-ion mass spectra

Derivatization is used to increase both negative‐ion sensitivity and positive‐ion sequence information in the liquid secondary‐ion mass spectra (LSIMS) of a series of peptides. The derivatization method involves acylation with pentafluorobenzyl fluoride in a single‐step reaction, and the reaction mi...

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Veröffentlicht in:	Rapid communications in mass spectrometry 1992-12, Vol.6 (12), p.747-752
Hauptverfasser:	Kiplinger, Jeffrey P., Contillo, Leonard, Hendrick, W. Lee, Grodski, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Angiotensin III - analysis Biological and medical sciences Bradykinin - analysis Chromatography, High Pressure Liquid Enkephalin, Leucine - analysis Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry General aspects, investigation methods Indicators and Reagents Molecular Sequence Data Peptides - isolation & purification Proteins
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