Coronary Heart Disease in HIV-Infected Individuals
It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected indiv...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2003-08, Vol.33 (4), p.506-512 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Currier, Judith S Taylor, Anne Boyd, Felicity Dezii, Christopher M Kawabata, Hugh Burtcel, Beth Maa, Jen-Fue Hodder, Sally |
| description | It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care. |
| doi_str_mv | 10.1097/00126334-200308010-00012 |
| format | Article |
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In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00126334-200308010-00012</identifier><identifier>PMID: 12869840</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; AIDS/HIV ; Biological and medical sciences ; Cardiovascular disease ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary Disease - prevention & control ; Drug therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Health risk assessment ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Primary care ; Regression Analysis ; Risk Factors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2003-08, Vol.33 (4), p.506-512</ispartof><rights>2003 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Aug 1, 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5602-4444cba5c565264d6fbd07333ba774b962786968cdd4aee954394ac7e08732d73</citedby><cites>FETCH-LOGICAL-c5602-4444cba5c565264d6fbd07333ba774b962786968cdd4aee954394ac7e08732d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00126334-200308010-00012$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15015085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12869840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Currier, Judith S</creatorcontrib><creatorcontrib>Taylor, Anne</creatorcontrib><creatorcontrib>Boyd, Felicity</creatorcontrib><creatorcontrib>Dezii, Christopher M</creatorcontrib><creatorcontrib>Kawabata, Hugh</creatorcontrib><creatorcontrib>Burtcel, Beth</creatorcontrib><creatorcontrib>Maa, Jen-Fue</creatorcontrib><creatorcontrib>Hodder, Sally</creatorcontrib><title>Coronary Heart Disease in HIV-Infected Individuals</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - etiology</subject><subject>Coronary Disease - prevention & control</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risk assessment</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Primary care</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9rFDEQgIMotlb_hbIU9G11kkx-7GO5Vu-g4Iv6GrLJLN12b7cmuy3-9-a804JQGgKThG8mmS-MVRw-cmjMJwAutJRYCwAJFjjUsDt7wY55g1gba_FlWSuhauRSHbE3Od8UQiM2r9kRF1Y3FuGYidWUptGnX9WafJqriz6Tz1T1Y7Xe_Kg3Y0dhplhtxtjf93HxQ37LXnUl0LtDPGHfP19-W63rq69fNqvzqzooDaLGMkLrVdkpoTHqro1gpJStNwbbRgtTHqFtiBE9UaNQNuiDIbBGimjkCfuwr3uXpp8L5dlt-xxoGPxI05KdkWiU4OpZkFuruUFdwLP_wJtpSWNpwgkpi1AFu2vtHgppyjlR5-5Svy2GHAe3s-_-2nf_7Ls_9kvq6aH-0m4pPiYedBfg_QHwOfihS34MfX7kFJRpdx3hnnuYhplSvh2WB0rumvwwX7unfl_-Bno-mDU</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Currier, Judith S</creator><creator>Taylor, Anne</creator><creator>Boyd, Felicity</creator><creator>Dezii, Christopher M</creator><creator>Kawabata, Hugh</creator><creator>Burtcel, Beth</creator><creator>Maa, Jen-Fue</creator><creator>Hodder, Sally</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Coronary Heart Disease in HIV-Infected Individuals</title><author>Currier, Judith S ; Taylor, Anne ; Boyd, Felicity ; Dezii, Christopher M ; Kawabata, Hugh ; Burtcel, Beth ; Maa, Jen-Fue ; Hodder, Sally</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5602-4444cba5c565264d6fbd07333ba774b962786968cdd4aee954394ac7e08732d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - etiology</topic><topic>Coronary Disease - prevention & control</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health risk assessment</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Primary care</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Currier, Judith S</creatorcontrib><creatorcontrib>Taylor, Anne</creatorcontrib><creatorcontrib>Boyd, Felicity</creatorcontrib><creatorcontrib>Dezii, Christopher M</creatorcontrib><creatorcontrib>Kawabata, Hugh</creatorcontrib><creatorcontrib>Burtcel, Beth</creatorcontrib><creatorcontrib>Maa, Jen-Fue</creatorcontrib><creatorcontrib>Hodder, Sally</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Currier, Judith S</au><au>Taylor, Anne</au><au>Boyd, Felicity</au><au>Dezii, Christopher M</au><au>Kawabata, Hugh</au><au>Burtcel, Beth</au><au>Maa, Jen-Fue</au><au>Hodder, Sally</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary Heart Disease in HIV-Infected Individuals</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>33</volume><issue>4</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>12869840</pmid><doi>10.1097/00126334-200308010-00012</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2003-08, Vol.33 (4), p.506-512 |
| issn | 1525-4135 1944-7884 |
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| subjects | Adolescent Adult Age Factors Aged AIDS/HIV Biological and medical sciences Cardiovascular disease Coronary Disease - epidemiology Coronary Disease - etiology Coronary Disease - prevention & control Drug therapy Female Fundamental and applied biological sciences. Psychology Health risk assessment HIV HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Incidence Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Primary care Regression Analysis Risk Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology |
| title | Coronary Heart Disease in HIV-Infected Individuals |
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