T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation
In a trial of prophylactic implantation of a defibrillator, a mortality benefit was seen among patients with previous myocardial infarction and a left-ventricular ejection fraction of 0·30 or less. We identified 129 similar patients from two previously published clinical trials in which microvolt T-...
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| Veröffentlicht in: | The Lancet (British edition) 2003-07, Vol.362 (9378), p.125-126 |
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| creator | Hohnloser, SH Ikeda, T Bloomfield, DM Dabbous, OH Cohen, RJ |
| description | In a trial of prophylactic implantation of a defibrillator, a mortality benefit was seen among patients with previous myocardial infarction and a left-ventricular ejection fraction of 0·30 or less. We identified 129 similar patients from two previously published clinical trials in which microvolt T-wave alternans testing was prospectively assessed. At 24 months of follow-up, no sudden cardiac death or cardiac arrest was seen among patients who tested T-wave alternans negative, compared with an event rate of 15·6% among the remaining patients. Testing of T-wave alternans seems to identify patients who are at low risk of ventricular tachyarrhythmic event and who may not benefit from defibrillator therapy. |
| doi_str_mv | 10.1016/S0140-6736(03)13865-2 |
| format | Article |
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We identified 129 similar patients from two previously published clinical trials in which microvolt T-wave alternans testing was prospectively assessed. At 24 months of follow-up, no sudden cardiac death or cardiac arrest was seen among patients who tested T-wave alternans negative, compared with an event rate of 15·6% among the remaining patients. Testing of T-wave alternans seems to identify patients who are at low risk of ventricular tachyarrhythmic event and who may not benefit from defibrillator therapy.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(03)13865-2</identifier><identifier>PMID: 12867114</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Legacy CDMS: Elsevier Ltd</publisher><subject>Clinical trials ; Death, Sudden, Cardiac - prevention & control ; Defibrillators ; Defibrillators, Implantable ; Electrocardiography ; Follow-Up Studies ; Heart ; Heart Arrest - prevention & control ; Heart attacks ; Humans ; Implantation ; Life Sciences (General) ; Medical research ; Mortality ; Myocardial infarction ; Myocardial Infarction - complications ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Patients ; Population ; Prospective Studies ; Space life sciences ; Stroke Volume ; Therapy ; Transplants & implants ; Ventricle ; Ventricular Dysfunction, Left - complications</subject><ispartof>The Lancet (British edition), 2003-07, Vol.362 (9378), p.125-126</ispartof><rights>2003 Elsevier Ltd</rights><rights>Copyright Lancet Ltd. 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Testing of T-wave alternans seems to identify patients who are at low risk of ventricular tachyarrhythmic event and who may not benefit from defibrillator therapy.</description><subject>Clinical trials</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Defibrillators</subject><subject>Defibrillators, Implantable</subject><subject>Electrocardiography</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart Arrest - prevention & control</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Implantation</subject><subject>Life Sciences (General)</subject><subject>Medical research</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Patients</subject><subject>Population</subject><subject>Prospective 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| subjects | Clinical trials Death, Sudden, Cardiac - prevention & control Defibrillators Defibrillators, Implantable Electrocardiography Follow-Up Studies Heart Heart Arrest - prevention & control Heart attacks Humans Implantation Life Sciences (General) Medical research Mortality Myocardial infarction Myocardial Infarction - complications Myocardial Infarction - physiopathology Myocardial Infarction - therapy Patients Population Prospective Studies Space life sciences Stroke Volume Therapy Transplants & implants Ventricle Ventricular Dysfunction, Left - complications |
| title | T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation |
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