Fluorescent In Situ Hybridization on Isolated Tumor Cell Nuclei: A Sensitive Method for 1p and 19q Deletion Analysis in Paraffin-Embedded Oligodendroglial Tumor Specimens

In oligodendroglial neoplasms, losses of chromosomal material at 1p and 19q associate with chemosensitivity and prolonged survival. Thus, 1p/19q testing is increasingly proposed for use in brain tumor diagnosis and prognostic assessment. Fluorescent in situ hybridization (FISH) is a classic techniqu...

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Veröffentlicht in:	Modern pathology 2003-07, Vol.16 (7), p.708-715
Hauptverfasser:	Gelpi, Ellen, Ambros, Inge M, Birner, Peter, Luegmayr, Andrea, Drlicek, Marcus, Fischer, Ingeborg, Kleinert, Reinhold, Maier, Hans, Huemer, Michael, Gatterbauer, Brigitte, Anton, Johann, Rössler, Karl, Budka, Herbert, Ambros, Peter F, Hainfellner, Johannes A
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Nucleus - chemistry Cell Nucleus - genetics Cell Nucleus - pathology Chemosensitivity Chromosome 1p Chromosome Deletion Chromosomes Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 DNA, Neoplasm - analysis Fluorescent in situ hybridization Humans Hybridization In Situ Hybridization, Fluorescence Laboratory Medicine Medical prognosis Medicine Medicine & Public Health methods-in-pathology Neoplasm Staging Neuroblastoma Neurology Neurosurgery Oligodendroglioma Oligodendroglioma - genetics Oligodendroglioma - pathology Oncology Paraffin Embedding Pathology Tumors
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