Direct coupled column separation and determination of the diastereomeric glucuronides of almokalant, a new class III antiarrhythmic drug, in human urine

A reversed‐phase coupled column separation (CCS) system for the analysis of two diastereomeric glucuronides of almokalant, a new class III antiarrhythmic drug, in human urine is described. After direct injection of urine samples (50 μl) the glucuronides were isolated by complex formation on a terbiu...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1992, Vol.4 (8), p.509-514
Hauptverfasser:	Stefansson, Morgan, Hoffmann, Kurt-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	almokalant glucuronides Analysis Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - classification Anti-Arrhythmia Agents - urine bioanalysis Biological and medical sciences Buffers Chromatography, Ion Exchange - instrumentation Chromatography, Ion Exchange - methods Chromatography, Ion Exchange - statistics & numerical data diastereomers General pharmacology Glucuronates - chemistry Glucuronates - urine Humans Medical sciences metal complexes Pharmacology. Drug treatments porous graphitic carbon Propanolamines - chemistry Propanolamines - urine Reproducibility of Results Sensitivity and Specificity Stereoisomerism Temperature
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