Diabetes insipidus and Langerhans cell histiocytosis: A case report of reversibility with 2-chlorodeoxyadenosine
Diabetes insipidus (DI) is the most common manifestation of central nervous system involvement in Langerhans cell histiocytosis (LCH). Patients with LCH involving the head and neck region are reported to have about a 40% lifetime chance of developing DI. The clinical and biochemical diagnosis of DI...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2003-07, Vol.25 (7), p.575-577 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | OTTAVIANO, Fabio FINLAY, Jonathan L |
| description | Diabetes insipidus (DI) is the most common manifestation of central nervous system involvement in Langerhans cell histiocytosis (LCH). Patients with LCH involving the head and neck region are reported to have about a 40% lifetime chance of developing DI. The clinical and biochemical diagnosis of DI is sometimes supported by the absence of the posterior pituitary bright signal on magnetic resonance images. Cladribine (2-chlorodeoxyadenosine, 2-CDA) has been reported as an active drug in children and adults with relapsed or refractory LCH. The authors report the successful reversal of DI in a 3-year-old child with established LCH using 2-CDA. |
| doi_str_mv | 10.1097/00043426-200307000-00017 |
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Patients with LCH involving the head and neck region are reported to have about a 40% lifetime chance of developing DI. The clinical and biochemical diagnosis of DI is sometimes supported by the absence of the posterior pituitary bright signal on magnetic resonance images. Cladribine (2-chlorodeoxyadenosine, 2-CDA) has been reported as an active drug in children and adults with relapsed or refractory LCH. The authors report the successful reversal of DI in a 3-year-old child with established LCH using 2-CDA.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/00043426-200307000-00017</identifier><identifier>PMID: 12847329</identifier><identifier>CODEN: JPHOFG</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Cladribine - therapeutic use ; Diabetes Insipidus - diagnosis ; Diabetes Insipidus - drug therapy ; Histiocytosis, Langerhans-Cell - diagnosis ; Histiocytosis, Langerhans-Cell - drug therapy ; Humans ; Immunosuppressive Agents - therapeutic use ; Infant ; Male ; Medical sciences ; Pharmacology. 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Patients with LCH involving the head and neck region are reported to have about a 40% lifetime chance of developing DI. The clinical and biochemical diagnosis of DI is sometimes supported by the absence of the posterior pituitary bright signal on magnetic resonance images. Cladribine (2-chlorodeoxyadenosine, 2-CDA) has been reported as an active drug in children and adults with relapsed or refractory LCH. The authors report the successful reversal of DI in a 3-year-old child with established LCH using 2-CDA.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Cladribine - therapeutic use</subject><subject>Diabetes Insipidus - diagnosis</subject><subject>Diabetes Insipidus - drug therapy</subject><subject>Histiocytosis, Langerhans-Cell - diagnosis</subject><subject>Histiocytosis, Langerhans-Cell - drug therapy</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQhq0KVL76Fypf4BbwF7HT22rpl7RSL3COJvak6yobp54sdP99vbDAwZoZ6Xk9mocxLsW1FI29EUIYbVRdKSG0sGWsypP2AzuVt7qudG3dUemFtZWR0pywM6I_e6KkPrITqZyxWjWnbLqL0OGMxONIcYphSxzGwFcw_sa8hpG4x2Hg60hzTH43J4r0hS-4B0KecUp55qkv3SNmil0c4rzjT3Fec1X59ZByCpj-7SDgWKIjXrDjHgbCT4d6zh6-fb1f_qhWv77_XC5WlddGzpUK6DonVFcLDWAh9EpiY63QwRkny5VgfagFht4G4_oOndU6SOiCNyZIfc6uXv6dcvq7RZrbTaT9KTBi2lJbTFhVS1FA9wL6nIgy9u2U4wbyrpWi3dtuX223b7bbZ9sl-vmwY9ttMLwHD3oLcHkAgDwMfYbRR3rnTNNI2Vj9H_eDibU</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>OTTAVIANO, Fabio</creator><creator>FINLAY, Jonathan L</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Diabetes insipidus and Langerhans cell histiocytosis: A case report of reversibility with 2-chlorodeoxyadenosine</title><author>OTTAVIANO, Fabio ; FINLAY, Jonathan L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-2de8b802b603aa7adf21e97703d8481153a7cd60edf7d48fbe8733d1abdc44d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Cladribine - therapeutic use</topic><topic>Diabetes Insipidus - diagnosis</topic><topic>Diabetes Insipidus - drug therapy</topic><topic>Histiocytosis, Langerhans-Cell - diagnosis</topic><topic>Histiocytosis, Langerhans-Cell - drug therapy</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OTTAVIANO, Fabio</creatorcontrib><creatorcontrib>FINLAY, Jonathan L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OTTAVIANO, Fabio</au><au>FINLAY, Jonathan L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes insipidus and Langerhans cell histiocytosis: A case report of reversibility with 2-chlorodeoxyadenosine</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>25</volume><issue>7</issue><spage>575</spage><epage>577</epage><pages>575-577</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><coden>JPHOFG</coden><abstract>Diabetes insipidus (DI) is the most common manifestation of central nervous system involvement in Langerhans cell histiocytosis (LCH). Patients with LCH involving the head and neck region are reported to have about a 40% lifetime chance of developing DI. The clinical and biochemical diagnosis of DI is sometimes supported by the absence of the posterior pituitary bright signal on magnetic resonance images. Cladribine (2-chlorodeoxyadenosine, 2-CDA) has been reported as an active drug in children and adults with relapsed or refractory LCH. The authors report the successful reversal of DI in a 3-year-old child with established LCH using 2-CDA.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>12847329</pmid><doi>10.1097/00043426-200307000-00017</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2003-07, Vol.25 (7), p.575-577 |
| issn | 1077-4114 1536-3678 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antineoplastic agents Biological and medical sciences Chemotherapy Cladribine - therapeutic use Diabetes Insipidus - diagnosis Diabetes Insipidus - drug therapy Histiocytosis, Langerhans-Cell - diagnosis Histiocytosis, Langerhans-Cell - drug therapy Humans Immunosuppressive Agents - therapeutic use Infant Male Medical sciences Pharmacology. Drug treatments Time Factors Treatment Outcome |
| title | Diabetes insipidus and Langerhans cell histiocytosis: A case report of reversibility with 2-chlorodeoxyadenosine |
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