Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor

Hemophilia A is a life-threatening, hemorrhagic, X-linked recessive disorder resulting in deficient factor VIII (FVIII) activity. After the infusion of therapeutic FVIII, 25% of patients develop anti-FVIII antibodies that inhibit FVIII procoagulant activity, thus precluding further administration of...

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Veröffentlicht in:	Blood 2003-08, Vol.102 (3), p.949-952
Hauptverfasser:	Villard, Sylvie, Lacroix-Desmazes, Sébastien, Kieber-Emmons, Thomas, Piquer, Dominique, Grailly, Sabrina, Benhida, Abdellah, Kaveri, Srini V., Saint-Remy, Jean-Marie, Granier, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibody Affinity Biological and medical sciences Epitopes Factor VIII - immunology Factor VIII - therapeutic use Hematologic and hematopoietic diseases Hemophilia A - drug therapy Hemophilia A - immunology Humans Isoantibodies - drug effects Medical sciences Peptide Library Peptides - immunology Peptides - pharmacology Peptides - therapeutic use Platelet diseases and coagulopathies
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