Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH

Familial adenomatous polyposis (FAP) and attenuated FAP are autosomal dominant disorders characterised by multiple colorectal adenomas and cancers. Both are caused by inherited mutations in the APC gene, and management includes genetic testing, colonoscopic surveillance, and prophylactic surgery for...

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Veröffentlicht in:	The Lancet (British edition) 2003-07, Vol.362 (9377), p.39-41
Hauptverfasser:	Sampson, Julian R, Dolwani, Sunil, Jones, Sian, Eccles, Diana, Ellis, Anthony, Evans, D Gareth, Frayling, Ian, Jordan, Sheila, Maher, Eamonn R, Mak, Tony, Maynard, Julie, Pigatto, Francesca, Shaw, Joan, Cheadle, Jeremy P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - epidemiology Adenomatous Polyposis Coli - genetics Adolescent Adult Aged Colorectal cancer Colorectal carcinoma Deoxyribonucleic acid DNA DNA Glycosylases Female Genes Genes, Recessive Genetic screening Genetics Humans Male Middle Aged Molecular Sequence Data Mutation N-Glycosyl Hydrolases - genetics Registries United Kingdom - epidemiology
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