Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs
Rats trained preoperatively to discriminate between acetic acid and caproic acid and between acetic acid and propionic acid were tested for their memory of these tasks and ability to discriminate between these odorants and between the enantiomers of carvone after receiving large bilateral bulbar les...
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| Veröffentlicht in: | Chemical senses 2003-06, Vol.28 (5), p.361-370 |
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| container_title | Chemical senses |
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| creator | BISULCO, Stephanie SLOTNICK, Burton |
| description | Rats trained preoperatively to discriminate between acetic acid and caproic acid and between acetic acid and propionic acid were tested for their memory of these tasks and ability to discriminate between these odorants and between the enantiomers of carvone after receiving large bilateral bulbar lesions that included most of the fatty acid responsive areas identified in prior physiological studies. Concentrations of acid odorants were varied to insure that discrimination was based on the qualitative difference between acids. Experimental rats performed somewhat poorer than controls on the memory test but had no significant deficits in performing the acid discrimination tasks or discriminating between the enantiomers of carvone. These results demonstrate that removal of most bulbar sites identified as responsive to fatty acids and the consequent disruption of patterned input to the bulb is largely without effect on discriminating odor qualities of structurally similar acids. |
| doi_str_mv | 10.1093/chemse/28.5.361 |
| format | Article |
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Concentrations of acid odorants were varied to insure that discrimination was based on the qualitative difference between acids. Experimental rats performed somewhat poorer than controls on the memory test but had no significant deficits in performing the acid discrimination tasks or discriminating between the enantiomers of carvone. These results demonstrate that removal of most bulbar sites identified as responsive to fatty acids and the consequent disruption of patterned input to the bulb is largely without effect on discriminating odor qualities of structurally similar acids.</description><identifier>ISSN: 0379-864X</identifier><identifier>ISSN: 1464-3553</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/28.5.361</identifier><identifier>PMID: 12826532</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Discrimination (Psychology) - drug effects ; Fatty Acids - chemistry ; Fatty Acids - pharmacology ; Fundamental and applied biological sciences. 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Concentrations of acid odorants were varied to insure that discrimination was based on the qualitative difference between acids. Experimental rats performed somewhat poorer than controls on the memory test but had no significant deficits in performing the acid discrimination tasks or discriminating between the enantiomers of carvone. These results demonstrate that removal of most bulbar sites identified as responsive to fatty acids and the consequent disruption of patterned input to the bulb is largely without effect on discriminating odor qualities of structurally similar acids.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - pathology</subject><subject>Olfactory Bulb - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Smell - drug effects</subject><subject>Smell - physiology</subject><issn>0379-864X</issn><issn>1464-3553</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoTtu6didB0F115_1YyuALBmaj4C7cSiVWDenKmKSR_vdm6MYBN8KFy4XvHLjnIPSakh0llu_9HA417JnZyR1X9AnaUKHEwKXkT9GGcG0Ho8SPK_Si1jtCqODMPEdXlBmmJGcblG9TBN9yOeFpqb4sh2WFtuQV54jrnEvDfoZlxRFaO2Hwy1RxPwu0in8vbcYJys-AxyVBCwUSTqF2eX3Qtzng_Nd_PKaxvkTPIqQaXl32Fn3_9PHb9Zfh5vbz1-sPN4MXjLXBWtCRUD9FqScaI6MT56CDVYGpSRkIICgNMhJjFCVM9QmT8VqORAGRfIven33vS_51DLW5Q38vpARryMfqNBeaaK3_C1KjrRHWdvDtP-BdPpa1P-GotYxb29Pdov0Z8iXXWkJ09z1SKCdHiXtozJ0bc8w46XpjXfHmYnscD2F65C8VdeDdBYDqIcUCq1_qIyesFFoQ_gdsJ6CZ</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>BISULCO, Stephanie</creator><creator>SLOTNICK, Burton</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs</title><author>BISULCO, Stephanie ; SLOTNICK, Burton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-99a7f01cdf57d1ff21d33a7e96e26d68aea411e5f08861026026ed8c75b06a053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Fatty Acids - chemistry</topic><topic>Fatty Acids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - pathology</topic><topic>Olfactory Bulb - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Smell - drug effects</topic><topic>Smell - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BISULCO, Stephanie</creatorcontrib><creatorcontrib>SLOTNICK, Burton</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BISULCO, Stephanie</au><au>SLOTNICK, Burton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem Senses</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>28</volume><issue>5</issue><spage>361</spage><epage>370</epage><pages>361-370</pages><issn>0379-864X</issn><issn>1464-3553</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>Rats trained preoperatively to discriminate between acetic acid and caproic acid and between acetic acid and propionic acid were tested for their memory of these tasks and ability to discriminate between these odorants and between the enantiomers of carvone after receiving large bilateral bulbar lesions that included most of the fatty acid responsive areas identified in prior physiological studies. Concentrations of acid odorants were varied to insure that discrimination was based on the qualitative difference between acids. Experimental rats performed somewhat poorer than controls on the memory test but had no significant deficits in performing the acid discrimination tasks or discriminating between the enantiomers of carvone. These results demonstrate that removal of most bulbar sites identified as responsive to fatty acids and the consequent disruption of patterned input to the bulb is largely without effect on discriminating odor qualities of structurally similar acids.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12826532</pmid><doi>10.1093/chemse/28.5.361</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0379-864X |
| ispartof | Chemical senses, 2003-06, Vol.28 (5), p.361-370 |
| issn | 0379-864X 1464-3553 1464-3553 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Discrimination (Psychology) - drug effects Fatty Acids - chemistry Fatty Acids - pharmacology Fundamental and applied biological sciences. Psychology Male Memory - drug effects Olfactory Bulb - drug effects Olfactory Bulb - pathology Olfactory Bulb - physiopathology Rats Rats, Sprague-Dawley Smell - drug effects Smell - physiology |
| title | Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs |
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