A Water-Soluble Azobenzene Cross-Linker for Photocontrol of Peptide Conformation

We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on...

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Veröffentlicht in:	Bioconjugate chemistry 2003-07, Vol.14 (4), p.824-829
Hauptverfasser:	Zhang, Zhihua, Burns, Darcy C, Kumita, Janet R, Smart, Oliver S, Woolley, G. Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemistry Azo Compounds - chemical synthesis Azo Compounds - chemistry Circular Dichroism Cross-Linking Reagents - chemistry Models, Chemical Models, Molecular Molecular Sequence Data Molecular Structure Peptides - chemistry Photochemistry Protein Conformation Spectrophotometry, Ultraviolet Stereoisomerism Thermodynamics Water - chemistry
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