MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients

P-glycoprotein, a membrane-localized protein transporter, codified by the MDR1 gene, influences the response to pharmacological treatments, including antiretroviral drugs. MDR1 polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism...

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Veröffentlicht in:	AIDS (London) 2003-07, Vol.17 (11), p.1696-1698
Hauptverfasser:	NASI, Milena, BORGHI, Vanni, COSSARIZZA, Andrea, PINTI, Marcello, BELLODI, Cristian, LUGLI, Enrico, MAFFEI, Stefania, TROIANO, Leonarda, RICHELDI, Luca, MUSSINI, Cristina, ESPOSITO, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 Lymphocyte Count Genes, MDR HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Protease Inhibitors - therapeutic use Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Polymorphism, Genetic Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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