Enantioseparation of erythro-mefloquine and its analogues in capillary electrophoresis

The enantioseparations of the chiral antimalaria drug ( R, S)- erythro-α-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol ( erythro-mefloquine, erythro-MQ) and its analogues were studied by capillary electrophoresis (CE) using cyclodextrins (CDs) as chiral selectors. The emphasis was put o...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2003-04, Vol.32 (1), p.41-49
Hauptverfasser:	Chankvetadze, Bezhan, Burjanadze, Naira, Blaschke, Gottfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Antimalarials - chemistry Antimalarials - isolation & purification Capillary electrophoresis Chemistry Cyclodextrins Cyclodextrins - chemistry Electrophoresis, Capillary - methods Enantiomer migration order Enantiomer separation erythro-Mefloquine Exact sciences and technology Mefloquine - analogs & derivatives Mefloquine - chemistry Mefloquine - isolation & purification Miscellaneous Reproducibility of Results Sensitivity and Specificity Stereoisomerism
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