Effects of homocysteine on l-arginine transport and nitric oxide formation in human platelets

Background Recent evidence indicates that hyperhomocysteinaemia is an independent risk factor for atherosclerosis, thrombosis and other cardiovascular diseases. This may be secondary to impaired fibrinolysis or increased platelet reactivity. Nitric oxide (NO), a product from l‐arginine by NOS and po...

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Veröffentlicht in:	European journal of clinical investigation 2003-08, Vol.33 (8), p.713-719
Hauptverfasser:	Leoncini, G., Pascale, R., Signorello, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - metabolism Biological and medical sciences Biological Transport - drug effects Blood Platelets - drug effects Blood Platelets - metabolism Ca2 Calcium - metabolism Cell-Free System - metabolism Dose-Response Relationship, Drug Ethylmaleimide - pharmacology Hematology homocysteine Homocysteine - pharmacology human platelets Humans Investigative techniques, diagnostic techniques (general aspects) l-arginine transport Leucine - pharmacology Medical sciences nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet Aggregation - physiology
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