Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen–glucose deprivation

Donepezil hydrochloride (donepezil: (±)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride) is a potent acetylcholinesterase inhibitor used for treatment of Alzheimer's disease. Although acetylcholinesterase inhibitors are used as a symptomatic treatment for Alzheime...

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Veröffentlicht in:	European journal of pharmacology 2003-07, Vol.472 (1), p.57-63
Hauptverfasser:	Akasofu, Shigeru, Kosasa, Takashi, Kimura, Manami, Kubota, Atsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase inhibitor Animals Biological and medical sciences Cell Culture Techniques Cell Hypoxia - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Donepezil Glucose - metabolism Indans - pharmacology LDH release Medical sciences Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Oxygen - metabolism Oxygen–glucose deprivation Piperidines - pharmacology Primary cultured cerebral cortical neuron Rat Rats Rats, Wistar
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