A Bicyclic Monoterpene Diol and UVB Stimulate BRCA1 Phosphorylation in Human Keratinocytes

BRCA1 (breast cancer–associated gene 1) is a tumor suppressor gene that plays a role in DNA repair when phosphorylated. Many DNA-damaging agents including UVC and hydrogen peroxide have been shown to induce phosphorylation of BRCA1. Results of this study now show that both UVB and a bicyclic monoter...

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Veröffentlicht in:	Photochemistry and photobiology 2003-01, Vol.77 (1), p.46-51
Hauptverfasser:	Canning, Matthew T., Brown, David A., Yarosh, Daniel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 Protein - metabolism Cell Line Dichlororibofuranosylbenzimidazole - pharmacology DNA Repair - drug effects Dose-Response Relationship, Drug ENVIRONMENTAL PHOTOBIOLOGY AND UVR EFFECTS Humans Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Monoterpenes - pharmacology Norbornanes - pharmacology Oxadiazoles - pharmacology Phosphorylation - drug effects Phosphorylation - radiation effects Pyrimidine Dimers - radiation effects Quinoxalines - pharmacology Sirolimus - pharmacology Time Factors Ultraviolet Rays
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