Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD), Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies (Drosophila melanogaster). The purpose of this study was to determine whether life-extending effects persist if the recipient...

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Veröffentlicht in:	The Journal of biological chemistry 2003-07, Vol.278 (29), p.26418-26422
Hauptverfasser:	Orr, William C., Mockett, Robin J., Benes, Judith J., Sohal, Rajindar S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Animals Animals, Genetically Modified Antioxidants - metabolism Catalase - genetics Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Female Gene Dosage Gene Expression Genes, Insect Longevity - genetics Longevity - physiology Male Superoxide Dismutase - genetics Thioredoxin-Disulfide Reductase - genetics
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