Aberrant cutaneous weal and flare responses in chronic urticaria
This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine p...
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| Veröffentlicht in: | Acta dermato-venereologica 1992-11, Vol.72 (6), p.451-453 |
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| container_title | Acta dermato-venereologica |
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| creator | SHALL, L SAIHAN, E. M |
| description | This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). Five minutes after each injection, the area of the resulting weal and flare was calculated by computer-aided planimetry. The process was repeated at 15, 30 and 45 min following the injection. In patients, saline flares were significantly larger than those of the volunteers at 15, 30 and 45 min (p < 0.05). However, histamine and codeine flare areas were significantly smaller in the patients when compared to the controls at 15, 30 and 45 min (p < 0.05). Compound 48/80 produced smaller reactions in the patients without reaching statistical significance. |
| doi_str_mv | 10.2340/0001555572451453 |
| format | Article |
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M</creator><creatorcontrib>SHALL, L ; SAIHAN, E. M</creatorcontrib><description>This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). Five minutes after each injection, the area of the resulting weal and flare was calculated by computer-aided planimetry. The process was repeated at 15, 30 and 45 min following the injection. In patients, saline flares were significantly larger than those of the volunteers at 15, 30 and 45 min (p < 0.05). However, histamine and codeine flare areas were significantly smaller in the patients when compared to the controls at 15, 30 and 45 min (p < 0.05). Compound 48/80 produced smaller reactions in the patients without reaching statistical significance.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.2340/0001555572451453</identifier><identifier>PMID: 1362842</identifier><identifier>CODEN: ADVEA4</identifier><language>eng</language><publisher>Uppsala: Acta dermato-venereologica</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Chronic Disease ; Codeine ; Dermatology ; Female ; Histamine - analogs & derivatives ; Humans ; Injections, Intradermal ; Male ; Mast Cells - drug effects ; Medical sciences ; Middle Aged ; p-Methoxy-N-methylphenethylamine ; Skin - drug effects ; Skin - pathology ; Skin involvement in other diseases. Miscellaneous. 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M</creatorcontrib><title>Aberrant cutaneous weal and flare responses in chronic urticaria</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). Five minutes after each injection, the area of the resulting weal and flare was calculated by computer-aided planimetry. The process was repeated at 15, 30 and 45 min following the injection. In patients, saline flares were significantly larger than those of the volunteers at 15, 30 and 45 min (p < 0.05). However, histamine and codeine flare areas were significantly smaller in the patients when compared to the controls at 15, 30 and 45 min (p < 0.05). Compound 48/80 produced smaller reactions in the patients without reaching statistical significance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Codeine</subject><subject>Dermatology</subject><subject>Female</subject><subject>Histamine - analogs & derivatives</subject><subject>Humans</subject><subject>Injections, Intradermal</subject><subject>Male</subject><subject>Mast Cells - drug effects</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>p-Methoxy-N-methylphenethylamine</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Sodium Chloride</subject><subject>Urticaria - pathology</subject><subject>Urticaria - physiopathology</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1LxDAQxYMo67p69yLkIN6qSSZp05vL4hcseNFzSacTrHTbNWkR__vt0kXBuQzD773H8Bi7lOJWgRZ3QghpxsmUNlIbOGJzmRqZKGGyYzbf42TPT9lZjJ_jqYy0MzaTkCqr1ZzdL0sKwbU9x6F3LXVD5N_kGu7aivvGBeKB4rZrI0Vetxw_QtfWyIfQ1-hC7c7ZiXdNpIvDXrD3x4e31XOyfn16WS3XCYK0faIdgc-0JMxKVYHyHtFCnlvjXe7BOlXJDKFCVF5aQLIoS-81gSnzCgAW7GbK3Ybua6DYF5s6IjXN9HSRgU4B8nQUikmIoYsxkC-2od648FNIUexLK_6XNlquDtlDuaHqzzC1NPLrA3cRXePHvrCOvzKtcwGgYAdGrnPi</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>SHALL, L</creator><creator>SAIHAN, E. M</creator><general>Acta dermato-venereologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>Aberrant cutaneous weal and flare responses in chronic urticaria</title><author>SHALL, L ; SAIHAN, E. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-4ae3f741ec7b2d32ffcc839985fa9f38a2d17c3dcc2f183ce8c1bff4e35b9d333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Codeine</topic><topic>Dermatology</topic><topic>Female</topic><topic>Histamine - analogs & derivatives</topic><topic>Humans</topic><topic>Injections, Intradermal</topic><topic>Male</topic><topic>Mast Cells - drug effects</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>p-Methoxy-N-methylphenethylamine</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Sodium Chloride</topic><topic>Urticaria - pathology</topic><topic>Urticaria - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHALL, L</creatorcontrib><creatorcontrib>SAIHAN, E. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHALL, L</au><au>SAIHAN, E. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant cutaneous weal and flare responses in chronic urticaria</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>72</volume><issue>6</issue><spage>451</spage><epage>453</epage><pages>451-453</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). Five minutes after each injection, the area of the resulting weal and flare was calculated by computer-aided planimetry. The process was repeated at 15, 30 and 45 min following the injection. In patients, saline flares were significantly larger than those of the volunteers at 15, 30 and 45 min (p < 0.05). However, histamine and codeine flare areas were significantly smaller in the patients when compared to the controls at 15, 30 and 45 min (p < 0.05). Compound 48/80 produced smaller reactions in the patients without reaching statistical significance.</abstract><cop>Uppsala</cop><pub>Acta dermato-venereologica</pub><pmid>1362842</pmid><doi>10.2340/0001555572451453</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta dermato-venereologica, 1992-11, Vol.72 (6), p.451-453 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Biological and medical sciences Chronic Disease Codeine Dermatology Female Histamine - analogs & derivatives Humans Injections, Intradermal Male Mast Cells - drug effects Medical sciences Middle Aged p-Methoxy-N-methylphenethylamine Skin - drug effects Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Sodium Chloride Urticaria - pathology Urticaria - physiopathology |
| title | Aberrant cutaneous weal and flare responses in chronic urticaria |
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