Formation and Stability of the Enolates of N-Protonated Proline Methyl Ester and Proline Zwitterion in Aqueous Solution:  A Nonenzymatic Model for the First Step in the Racemization of Proline Catalyzed by Proline Racemase

Rate constants for the hydrolysis of l-proline methyl ester to form proline and methanol in D2O buffered at neutral pD and 25 °C and the deuterium enrichment of the proline product determined by electrospray ionization mass spectrometry are reported. The data give k DO = 5.3 ± 0.5 M-1 s-1 as the sec...

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Veröffentlicht in:	Biochemistry (Easton) 2003-07, Vol.42 (27), p.8354-8361
Hauptverfasser:	Williams, Glenn, Maziarz, E. Peter, Amyes, Tina L, Wood, Troy D, Richard, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Esterification Models, Chemical Proline - chemistry
Online-Zugang:	Volltext
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