Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)
The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 μm) were mounted in a pressurized myograph system and Ang-(1–7) concentrat...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2003-08, Vol.144 (8), p.3338-3343 |
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| creator | Neves, Liomar A. A Williams, Aleck F Averill, David B Ferrario, Carlos M Walkup, Michael P Brosnihan, K. Bridget |
| description | The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 μm) were mounted in a pressurized myograph system and Ang-(1–7) concentration-dependent response curves (10−10–10−5 m) were determined in arteries preconstricted with endothelin-1 (10−7 m). The Ang-(1–7) response was investigated in vessels with and without pretreatment with the Ang-(1–7) antagonist [d-[Ala7]-Ang-(1–7)] (10−7 m). Ang-(1–7) caused a significantly enhanced, concentration-dependent dilation of mesenteric vessels (EC50 = 2.7 nm) from pregnant compared with virgin female rats. d-[Ala7]-Ang-(1–7) eliminated the vasodilator effect of Ang-(1–7). There was no significant change in plasma concentration of Ang-(1–7) in pregnant animals. On the other hand, 24 h urinary excretion and kidney concentration of Ang-(1–7) were significantly higher in pregnant animals. The increased mesenteric dilation to Ang-(1–7) with enhanced kidney concentration and 24 h urinary excretion rate of Ang-(1–7) suggests an important role for this peptide in cardiovascular regulation during pregnancy. |
| doi_str_mv | 10.1210/en.2003-0009 |
| format | Article |
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A ; Williams, Aleck F ; Averill, David B ; Ferrario, Carlos M ; Walkup, Michael P ; Brosnihan, K. Bridget</creator><creatorcontrib>Neves, Liomar A. A ; Williams, Aleck F ; Averill, David B ; Ferrario, Carlos M ; Walkup, Michael P ; Brosnihan, K. Bridget</creatorcontrib><description>The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 μm) were mounted in a pressurized myograph system and Ang-(1–7) concentration-dependent response curves (10−10–10−5 m) were determined in arteries preconstricted with endothelin-1 (10−7 m). The Ang-(1–7) response was investigated in vessels with and without pretreatment with the Ang-(1–7) antagonist [d-[Ala7]-Ang-(1–7)] (10−7 m). Ang-(1–7) caused a significantly enhanced, concentration-dependent dilation of mesenteric vessels (EC50 = 2.7 nm) from pregnant compared with virgin female rats. d-[Ala7]-Ang-(1–7) eliminated the vasodilator effect of Ang-(1–7). There was no significant change in plasma concentration of Ang-(1–7) in pregnant animals. On the other hand, 24 h urinary excretion and kidney concentration of Ang-(1–7) were significantly higher in pregnant animals. The increased mesenteric dilation to Ang-(1–7) with enhanced kidney concentration and 24 h urinary excretion rate of Ang-(1–7) suggests an important role for this peptide in cardiovascular regulation during pregnancy.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2003-0009</identifier><identifier>PMID: 12865311</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Angiotensin ; Angiotensin I - analysis ; Angiotensin I - pharmacology ; Angiotensin I - urine ; Animals ; Arteries ; Biological and medical sciences ; Endothelin 1 ; Excretion ; Female ; Fundamental and applied biological sciences. Psychology ; Kidney - chemistry ; Kidneys ; Mesenteric Arteries - drug effects ; Mesenteric Arteries - physiology ; Peptide Fragments - analysis ; Peptide Fragments - pharmacology ; Peptide Fragments - urine ; Pregnancy ; Pregnancy, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Renal function ; Vasoactive agents ; Vasodilation - drug effects ; Vasodilators ; Veins & arteries</subject><ispartof>Endocrinology (Philadelphia), 2003-08, Vol.144 (8), p.3338-3343</ispartof><rights>Copyright © 2003 by The Endocrine Society 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright © 2003 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-41e20b70a5d440636996f58e515334ae006e4c7ef67c02f0c8ed1de86e3713873</citedby><cites>FETCH-LOGICAL-c459t-41e20b70a5d440636996f58e515334ae006e4c7ef67c02f0c8ed1de86e3713873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14980543$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12865311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neves, Liomar A. A</creatorcontrib><creatorcontrib>Williams, Aleck F</creatorcontrib><creatorcontrib>Averill, David B</creatorcontrib><creatorcontrib>Ferrario, Carlos M</creatorcontrib><creatorcontrib>Walkup, Michael P</creatorcontrib><creatorcontrib>Brosnihan, K. Bridget</creatorcontrib><title>Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 μm) were mounted in a pressurized myograph system and Ang-(1–7) concentration-dependent response curves (10−10–10−5 m) were determined in arteries preconstricted with endothelin-1 (10−7 m). The Ang-(1–7) response was investigated in vessels with and without pretreatment with the Ang-(1–7) antagonist [d-[Ala7]-Ang-(1–7)] (10−7 m). Ang-(1–7) caused a significantly enhanced, concentration-dependent dilation of mesenteric vessels (EC50 = 2.7 nm) from pregnant compared with virgin female rats. d-[Ala7]-Ang-(1–7) eliminated the vasodilator effect of Ang-(1–7). There was no significant change in plasma concentration of Ang-(1–7) in pregnant animals. On the other hand, 24 h urinary excretion and kidney concentration of Ang-(1–7) were significantly higher in pregnant animals. The increased mesenteric dilation to Ang-(1–7) with enhanced kidney concentration and 24 h urinary excretion rate of Ang-(1–7) suggests an important role for this peptide in cardiovascular regulation during pregnancy.</description><subject>Angiotensin</subject><subject>Angiotensin I - analysis</subject><subject>Angiotensin I - pharmacology</subject><subject>Angiotensin I - urine</subject><subject>Animals</subject><subject>Arteries</subject><subject>Biological and medical sciences</subject><subject>Endothelin 1</subject><subject>Excretion</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney - chemistry</subject><subject>Kidneys</subject><subject>Mesenteric Arteries - drug effects</subject><subject>Mesenteric Arteries - physiology</subject><subject>Peptide Fragments - analysis</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptide Fragments - urine</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal function</subject><subject>Vasoactive agents</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilators</subject><subject>Veins & arteries</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdFq1UAQhhdR7LF657UsiNqCqbPZzW5yeThULVSUYr0N282kTcnZTXdywN71HXwI38sncdMTOSB6Nczw8f__8DP2XMCRyAW8Q3-UA8gMAKoHbCEqVWRGGHjIFgBCZibPzR57QnSdVqWUfMz2RF7qQgqxYD-_RLz01rtbfuyv0kTi4xXypb_swoieOs8P0nKYHYhfdz_MIf9mKTRdb8cQ-RnSEDwhT9QnJPQjxs7xZZxmUrK-4SfeRbQ0656htz1fhWTkx2jHLvh76jx23sYU4nui76-hnUL8sX3KHrW2J3w2z312_v746-pjdvr5w8lqeZo5VVRjpgTmcGHAFo1SoKWuKt0WJRaikFJZBNConMFWGwd5C67ERjRYapRGyNLIffZ6qzvEcLNBGut1Rw773noMG6qNVFroQiXw5V_gddjE9BzVUkgotBFqknu7pVwMRBHbeojdOj1aC6in-mr09VRfPdWX8Bez6OZijc0OnvtKwKsZsORs38bUWEc7TlUlpHCJe7Plwmb4n2U2W8otib4JLrWAQ0Si3Tf_DPobhkm_2g</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Neves, Liomar A. A</creator><creator>Williams, Aleck F</creator><creator>Averill, David B</creator><creator>Ferrario, Carlos M</creator><creator>Walkup, Michael P</creator><creator>Brosnihan, K. Bridget</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)</title><author>Neves, Liomar A. A ; Williams, Aleck F ; Averill, David B ; Ferrario, Carlos M ; Walkup, Michael P ; Brosnihan, K. Bridget</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-41e20b70a5d440636996f58e515334ae006e4c7ef67c02f0c8ed1de86e3713873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Angiotensin</topic><topic>Angiotensin I - analysis</topic><topic>Angiotensin I - pharmacology</topic><topic>Angiotensin I - urine</topic><topic>Animals</topic><topic>Arteries</topic><topic>Biological and medical sciences</topic><topic>Endothelin 1</topic><topic>Excretion</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kidney - chemistry</topic><topic>Kidneys</topic><topic>Mesenteric Arteries - drug effects</topic><topic>Mesenteric Arteries - physiology</topic><topic>Peptide Fragments - analysis</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptide Fragments - urine</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renal function</topic><topic>Vasoactive agents</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilators</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neves, Liomar A. A</creatorcontrib><creatorcontrib>Williams, Aleck F</creatorcontrib><creatorcontrib>Averill, David B</creatorcontrib><creatorcontrib>Ferrario, Carlos M</creatorcontrib><creatorcontrib>Walkup, Michael P</creatorcontrib><creatorcontrib>Brosnihan, K. 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A</au><au>Williams, Aleck F</au><au>Averill, David B</au><au>Ferrario, Carlos M</au><au>Walkup, Michael P</au><au>Brosnihan, K. Bridget</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>144</volume><issue>8</issue><spage>3338</spage><epage>3343</epage><pages>3338-3343</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 μm) were mounted in a pressurized myograph system and Ang-(1–7) concentration-dependent response curves (10−10–10−5 m) were determined in arteries preconstricted with endothelin-1 (10−7 m). The Ang-(1–7) response was investigated in vessels with and without pretreatment with the Ang-(1–7) antagonist [d-[Ala7]-Ang-(1–7)] (10−7 m). Ang-(1–7) caused a significantly enhanced, concentration-dependent dilation of mesenteric vessels (EC50 = 2.7 nm) from pregnant compared with virgin female rats. d-[Ala7]-Ang-(1–7) eliminated the vasodilator effect of Ang-(1–7). There was no significant change in plasma concentration of Ang-(1–7) in pregnant animals. On the other hand, 24 h urinary excretion and kidney concentration of Ang-(1–7) were significantly higher in pregnant animals. The increased mesenteric dilation to Ang-(1–7) with enhanced kidney concentration and 24 h urinary excretion rate of Ang-(1–7) suggests an important role for this peptide in cardiovascular regulation during pregnancy.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>12865311</pmid><doi>10.1210/en.2003-0009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Angiotensin Angiotensin I - analysis Angiotensin I - pharmacology Angiotensin I - urine Animals Arteries Biological and medical sciences Endothelin 1 Excretion Female Fundamental and applied biological sciences. Psychology Kidney - chemistry Kidneys Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Peptide Fragments - analysis Peptide Fragments - pharmacology Peptide Fragments - urine Pregnancy Pregnancy, Animal - physiology Rats Rats, Sprague-Dawley Renal function Vasoactive agents Vasodilation - drug effects Vasodilators Veins & arteries |
| title | Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7) |
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