Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo

Activation of programmed cell death in cancer cells offers novel and potentially useful approaches to improving patient responses to conventional chemotherapy. X-linked inhibitor of apoptosis ( XIAP ), is the most potent member of the IAP gene family in terms of its ability to inhibit caspases and s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2003-07, Vol.9 (7), p.2826-2836
Hauptverfasser:	Hu, YanPing, Cherton-Horvat, Gabriele, Dragowska, Visia, Baird, Stephen, Korneluk, Robert G, Durkin, Jon P, Mayer, Lawrence D, LaCasse, Eric C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Biological and medical sciences Blotting, Western Caspase 3 Caspases - metabolism Cell Line, Tumor Cell Nucleus - metabolism Cell Survival Chemotherapy DNA Fragmentation Dose-Response Relationship, Drug Down-Regulation Enzyme Inhibitors - pharmacology Flow Cytometry Humans In Vitro Techniques Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Mice Mice, SCID Microscopy, Confocal Neoplasm Transplantation Oligonucleotides, Antisense - pharmacology Pharmacology. Drug treatments Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors X-Linked Inhibitor of Apoptosis Protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!