VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

Vitamin D(3) upregulated protein 1 (VDUP1) is a 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) upregulated protein, and it is induced by various stresses. In human tumor tissues, VDUP1 expression was downregulated. Upon stimulation by growth-inhibitory signals such as TGF-beta1 and 1,25(OH)(2)D(3), it...

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Veröffentlicht in:	Oncogene 2003-06, Vol.22 (26), p.4035-4046
Hauptverfasser:	Han, Seung Hyun, Jeon, Jun Ho, Ju, Hyang Ran, Jung, Uhee, Kim, Kun Young, Yoo, Hyang Sook, Lee, Young Ho, Song, Kyu Sang, Hwang, Ho Myeung, Na, Yoon Sook, Yang, Young, Lee, Kee Nyung, Choi, Inpyo
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Blotting, Northern Calcitriol - metabolism Carrier Proteins - biosynthesis Cell Cycle Cell Differentiation Cell Division Cell Line Cyclin A - metabolism Cyclin A2 Disease Progression DNA-Binding Proteins - metabolism Fanconi Anemia - metabolism Flow Cytometry G1 Phase Genes, Reporter Histone Deacetylase 1 Histone Deacetylases - metabolism HL-60 Cells Humans In Situ Hybridization Interleukin-3 - metabolism Jurkat Cells Kruppel-Like Transcription Factors Mice Microscopy, Fluorescence Neoplasms - metabolism Promoter Regions, Genetic Promyelocytic Leukemia Zinc Finger Protein Repressor Proteins Resting Phase, Cell Cycle Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction Thioredoxins Time Factors Transcription Factors - metabolism Transcription, Genetic Transfection Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 Tumor Cells, Cultured Up-Regulation Zinc Fingers
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