Cyclin E overexpression enhances cytokine-mediated apoptosis in MCF7 breast cancer cells

Cyclin E, the regulatory component of the cyclin E/cyclin-dependent kinase (CDK) complex, is required for proliferation and overexpression of this cyclin is associated with many types of human tumors. To elucidate the mechanism by which cyclin E overexpression promotes tumorigenesis, cyclin E was ov...

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Veröffentlicht in:	Genes and immunity 2003-07, Vol.4 (5), p.336-342
Hauptverfasser:	Dhillon, N K, Mudryj, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Apoptosis - physiology Apoptosis Regulatory Proteins Bax protein Bcl-2 protein Bcl-x protein Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer cells Cancer Research Cell Line, Tumor Cyclin E Cyclin E - genetics Cyclin E - metabolism Cyclin-dependent kinase Cyclin-dependent kinases Cytokines Cytokines - metabolism Death Domain Receptor Signaling Adaptor Proteins full-paper Fundamental and applied biological sciences. Psychology Gene Expression Health aspects Homeostasis Human Genetics Humans Immunology Kinases Mcl-1 protein Membrane Glycoproteins - metabolism Microbiology Physiological aspects Receptors, Tumor Necrosis Factor - metabolism Risk factors TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Tumorigenesis
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