Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia

In order to clarify the reasons for the reduced Hb A2 levels in Sardinian delta beta-thalassemia, we characterized, both by cloning and sequence analysis and by direct sequencing of amplified DNA, the delta-globin gene from an individual of Sardinian descent who is a compound heterozygote for the be...

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Veröffentlicht in:	Hemoglobin 1992, Vol.16 (6), p.503-509
Hauptverfasser:	Loudianos, G, Moi, P, Lavinha, J, Galanello, R, Cao, A, Pirastu, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta-Thalassemia - genetics Cloning, Molecular DNA - analysis Gene Deletion Globins - genetics Hematologic Tests Heterozygote Humans Italy - epidemiology Male Reference Values Suppression, Genetic - genetics
Online-Zugang:	Volltext
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