Monocyte chemoattractant protein-1 involvement in the α-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice

We studied the effects of α-tocopheryl acetate supplementation on the development of fatty streaks and its ability to modulate the expression of monocyte chemoattractant protein (MCP)-1 in aortic lesions of apoliprotein E knockout mice. For this purpose, 16-week-old apolipoprotein E knockout mice re...

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Veröffentlicht in:	British journal of nutrition 2003-07, Vol.90 (1), p.3-11
Hauptverfasser:	Peluzio, Maria C. G., Miguel, Emir, Drumond, Thaís C., César, Giovana C., Santiago, Helton C., Teixeira, Mauro M., Vieira, Enio C., Arantes, Rosa M. E., Alvarez-Leite, Jacqueline I.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - metabolism alpha-Tocopherol - therapeutic use Animals Antioxidant Aortic Diseases - drug therapy Aortic Diseases - metabolism Aortic Diseases - pathology Apolipoprotein E knockout mice Apolipoproteins E - genetics Apolipoproteins E - metabolism Arteriosclerosis - drug therapy Arteriosclerosis - metabolism Arteriosclerosis - pathology Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cholesterol - blood Immunohistochemistry Lipoproteins - analysis Liver - chemistry Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Monocyte chemoattractant protein-1 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis α-Tocopherol
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