Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats
PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insul...
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| Veröffentlicht in: | Life sciences (1973) 2003-08, Vol.73 (11), p.1369-1381 |
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| container_title | Life sciences (1973) |
| container_volume | 73 |
| creator | Hirata, Aparecida Emiko Alvarez-Rojas, Fernanda Campello Carvalheira, José Barreto de Oliveira Carvalho, Carla Roberta Dolnikoff, Miriam Sterman Abdalla Saad, Mario José |
| description | PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance. |
| doi_str_mv | 10.1016/S0024-3205(03)00477-6 |
| format | Article |
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Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(03)00477-6</identifier><identifier>PMID: 12850498</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adipose Tissue - chemistry ; Adipose Tissue - metabolism ; Adiposity ; Aging ; Animals ; Animals, Newborn ; Insulin ; Insulin - pharmacology ; Insulin Receptor Substrate Proteins ; Insulin Resistance ; Intracellular Signaling Peptides and Proteins ; Liver - chemistry ; Liver - metabolism ; Male ; MSG ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphoproteins - analysis ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases - physiology ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-akt ; PTP1B ; Rats ; Rats, Wistar ; Receptor, Insulin - physiology ; Signal Transduction ; Sodium Glutamate - administration & dosage ; Tyrosine - metabolism</subject><ispartof>Life sciences (1973), 2003-08, Vol.73 (11), p.1369-1381</ispartof><rights>2003 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-80faa9a4e23da3397a706e39449447bf88b5eca041e8ee63c30e202f1edbbc353</citedby><cites>FETCH-LOGICAL-c361t-80faa9a4e23da3397a706e39449447bf88b5eca041e8ee63c30e202f1edbbc353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320503004776$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12850498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirata, Aparecida Emiko</creatorcontrib><creatorcontrib>Alvarez-Rojas, Fernanda</creatorcontrib><creatorcontrib>Campello Carvalheira, José Barreto</creatorcontrib><creatorcontrib>de Oliveira Carvalho, Carla Roberta</creatorcontrib><creatorcontrib>Dolnikoff, Miriam Sterman</creatorcontrib><creatorcontrib>Abdalla Saad, Mario José</creatorcontrib><title>Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.</description><subject>Adipose Tissue - chemistry</subject><subject>Adipose Tissue - metabolism</subject><subject>Adiposity</subject><subject>Aging</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin Receptor Substrate Proteins</subject><subject>Insulin Resistance</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>MSG</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphoproteins - analysis</subject><subject>Phosphorylation</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 1</subject><subject>Protein Tyrosine Phosphatases - physiology</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>PTP1B</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Insulin - physiology</subject><subject>Signal Transduction</subject><subject>Sodium Glutamate - administration & dosage</subject><subject>Tyrosine - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVpaDaPn9DiU0kPTkaW5ceptKFJAwlZspuzkKXxouKVU42ckH8f7YP2GBiQGL55fYx95nDOgVcXC4CizEUB8gzEN4CyrvPqA5vxpm5zqAT_yGb_kEN2RPQHAKSsxSd2yItGQtk2M2bvRjsNOrrRZ2Of3TxczJdz_jNzPmLQZpvX3mZ2fPEUA-p1Rm7l9eD8KkEpaEr_jNCTi-4Zs-iIJqRNt7vFdR50pBN20OuB8HT_HrPHq1_Ly9_57f31zeWP29yIise8gV7rVpdYCKuFaGtdQ4WiLcsUddc3TSfRaCg5NoiVMAKwgKLnaLvOCCmO2ddd36cw_k07RLV2ZHAYtMdxIlWLUsqi4AmUO9CEkShgr56CW-vwqjiojV611as27hQItdWrqlT3ZT9g6tZo_1ftfSbg-w7AdOazw6DIOPQGrQtoorKje2fEG2iXinQ</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Hirata, Aparecida Emiko</creator><creator>Alvarez-Rojas, Fernanda</creator><creator>Campello Carvalheira, José Barreto</creator><creator>de Oliveira Carvalho, Carla Roberta</creator><creator>Dolnikoff, Miriam Sterman</creator><creator>Abdalla Saad, Mario José</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats</title><author>Hirata, Aparecida Emiko ; Alvarez-Rojas, Fernanda ; Campello Carvalheira, José Barreto ; de Oliveira Carvalho, Carla Roberta ; Dolnikoff, Miriam Sterman ; Abdalla Saad, Mario José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-80faa9a4e23da3397a706e39449447bf88b5eca041e8ee63c30e202f1edbbc353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Adipose Tissue - metabolism</topic><topic>Adiposity</topic><topic>Aging</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Insulin</topic><topic>Insulin - pharmacology</topic><topic>Insulin Receptor Substrate Proteins</topic><topic>Insulin Resistance</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>MSG</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Phosphoproteins - analysis</topic><topic>Phosphorylation</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 1</topic><topic>Protein Tyrosine Phosphatases - physiology</topic><topic>Protein-Serine-Threonine Kinases</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-akt</topic><topic>PTP1B</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Insulin - physiology</topic><topic>Signal Transduction</topic><topic>Sodium Glutamate - administration & dosage</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirata, Aparecida Emiko</creatorcontrib><creatorcontrib>Alvarez-Rojas, Fernanda</creatorcontrib><creatorcontrib>Campello Carvalheira, José Barreto</creatorcontrib><creatorcontrib>de Oliveira Carvalho, Carla Roberta</creatorcontrib><creatorcontrib>Dolnikoff, Miriam Sterman</creatorcontrib><creatorcontrib>Abdalla Saad, Mario José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirata, Aparecida Emiko</au><au>Alvarez-Rojas, Fernanda</au><au>Campello Carvalheira, José Barreto</au><au>de Oliveira Carvalho, Carla Roberta</au><au>Dolnikoff, Miriam Sterman</au><au>Abdalla Saad, Mario José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>73</volume><issue>11</issue><spage>1369</spage><epage>1381</epage><pages>1369-1381</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>12850498</pmid><doi>10.1016/S0024-3205(03)00477-6</doi><tpages>13</tpages></addata></record> |
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| subjects | Adipose Tissue - chemistry Adipose Tissue - metabolism Adiposity Aging Animals Animals, Newborn Insulin Insulin - pharmacology Insulin Receptor Substrate Proteins Insulin Resistance Intracellular Signaling Peptides and Proteins Liver - chemistry Liver - metabolism Male MSG Muscle, Skeletal - chemistry Muscle, Skeletal - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - analysis Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - physiology Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt PTP1B Rats Rats, Wistar Receptor, Insulin - physiology Signal Transduction Sodium Glutamate - administration & dosage Tyrosine - metabolism |
| title | Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats |
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