A tail-artery cannulation method for the study of blood parameters in freely moving rats
The aim of this study was to improve the chronic tail-artery cannulation technique for repeated substance administration and blood sampling under stress-free conditions in freely moving rats. For that purpose, a special metal capsula and spring-tube system were developed, which not only protects the...
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| Veröffentlicht in: | Journal of pharmacological and toxicological methods 1992-09, Vol.28 (2), p.79-83 |
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| container_end_page | 83 |
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| container_issue | 2 |
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| container_title | Journal of pharmacological and toxicological methods |
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| creator | Hagmüller, Karl Liebmann, Peter Porta, Sepp Rinner, Ingo |
| description | The aim of this study was to improve the chronic tail-artery cannulation technique for repeated substance administration and blood sampling under stress-free conditions in freely moving rats. For that purpose, a special metal capsula and spring-tube system were developed, which not only protects the inserted cannula but also provides a less injurious insertion procedure and improves the animals' welfare as illustrated by normal cleaning and feeding behavior. Intraarterial application of test substances and repeated blood sampling can be done under minimal stress conditions as shown by unaltered plasma levels of highly stress-sensitive prolactin and the catecholamines (CA), epinephrine (E), norepinephrine (NE), and dopamine (DA), after infusion of 300 μL saline. |
| doi_str_mv | 10.1016/1056-8719(92)90051-2 |
| format | Article |
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Intraarterial application of test substances and repeated blood sampling can be done under minimal stress conditions as shown by unaltered plasma levels of highly stress-sensitive prolactin and the catecholamines (CA), epinephrine (E), norepinephrine (NE), and dopamine (DA), after infusion of 300 μL saline.</description><identifier>ISSN: 1056-8719</identifier><identifier>EISSN: 1873-488X</identifier><identifier>DOI: 10.1016/1056-8719(92)90051-2</identifier><identifier>PMID: 1482789</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blood Specimen Collection - methods ; Catecholamines - blood ; Catheterization - instrumentation ; Catheterization - methods ; Chromatography, High Pressure Liquid ; Chronic blood sampling ; Equipment Design ; Male ; Plasma catecholamines ; Plasma prolactin ; Prolactin - blood ; Radioimmunoassay ; Rats ; Rats, Wistar ; Sodium Chloride - administration & dosage ; Stress-free conditions ; Tail - blood supply ; Tail-artery cannulation</subject><ispartof>Journal of pharmacological and toxicological methods, 1992-09, Vol.28 (2), p.79-83</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d7feb20f384049a36ee248feae8dce21439c591dc9eab856d7a26b2aa51fcc963</citedby><cites>FETCH-LOGICAL-c357t-d7feb20f384049a36ee248feae8dce21439c591dc9eab856d7a26b2aa51fcc963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1056-8719(92)90051-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1482789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagmüller, Karl</creatorcontrib><creatorcontrib>Liebmann, Peter</creatorcontrib><creatorcontrib>Porta, Sepp</creatorcontrib><creatorcontrib>Rinner, Ingo</creatorcontrib><title>A tail-artery cannulation method for the study of blood parameters in freely moving rats</title><title>Journal of pharmacological and toxicological methods</title><addtitle>J Pharmacol Toxicol Methods</addtitle><description>The aim of this study was to improve the chronic tail-artery cannulation technique for repeated substance administration and blood sampling under stress-free conditions in freely moving rats. 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| fulltext | fulltext |
| identifier | ISSN: 1056-8719 |
| ispartof | Journal of pharmacological and toxicological methods, 1992-09, Vol.28 (2), p.79-83 |
| issn | 1056-8719 1873-488X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73455152 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Blood Specimen Collection - methods Catecholamines - blood Catheterization - instrumentation Catheterization - methods Chromatography, High Pressure Liquid Chronic blood sampling Equipment Design Male Plasma catecholamines Plasma prolactin Prolactin - blood Radioimmunoassay Rats Rats, Wistar Sodium Chloride - administration & dosage Stress-free conditions Tail - blood supply Tail-artery cannulation |
| title | A tail-artery cannulation method for the study of blood parameters in freely moving rats |
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