Calcium antagonistic effects of carbamazepine as a mechanism of action in neuropsychiatric disorders: studies in calcium dependent model epilepsies

Carbamazepine (CBZ) is used in neurology for the treatment of epilepsies and trigeminal neuralgia and in psychiatry for the prophylactic treatment of affective and schizoaffective psychoses. Since a common mechanism of epilepsies and affective psychoses might be increased intracelllular calcium ion...

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Veröffentlicht in:	European neuropsychopharmacology 1992-12, Vol.2 (4), p.455-462
Hauptverfasser:	Walden, J., Grunze, H., Bingmann, D., Liu, Z., Düsing, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective psychoses Animals Calcium antagonists Calcium Channel Blockers - pharmacology Carbamazepine Carbamazepine - pharmacology Carbamazepine - therapeutic use Epilepsy - drug therapy Epilepsy - physiopathology Extracellular Space - drug effects Extracellular Space - physiology Guinea Pigs Hippocampus - drug effects In Vitro Techniques Magnesium - physiology Microelectrodes Model epilepsies N-Methylaspartate - pharmacology Psychotic Disorders - drug therapy Psychotic Disorders - psychology Verapamil Verapamil - pharmacology
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