Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma

The mechanisms of fenretinide‐induced cell death of neuroblastoma cells are complex, involving signaling pathways mediated by free radicals or reactive oxygen species (ROS). The aim of this study was to identify mechanisms generating ROS and apoptosis of neuroblastoma cells in response to fenretinid...

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Veröffentlicht in:	Journal of cellular biochemistry 2003-07, Vol.89 (4), p.698-708
Hauptverfasser:	Lovat, Penny E., Ranalli, Marco, Corazzari, Marco, Raffaghello, Lizzia, Pearson, Andy D.J., Ponzoni, Mirco, Piacentini, Mauro, Melino, Gerry, Redfern, Christopher P.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology Blotting, Western Cytochrome P-450 Enzyme System - metabolism Eicosanoic Acids - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology fenretinide Fenretinide - pharmacology free radicals Free Radicals - metabolism Humans Leukotrienes - pharmacology lipoxygenase Lipoxygenase - metabolism NADPH Oxidases - metabolism neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Reactive Oxygen Species - metabolism Tumor Cells, Cultured
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