Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch
In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constr...
Gespeichert in:
| Veröffentlicht in: | Heart and vessels 1992-12, Vol.7 (4), p.196-199 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 199 |
|---|---|
| container_issue | 4 |
| container_start_page | 196 |
| container_title | Heart and vessels |
| container_volume | 7 |
| creator | AKOPOV, S. E GRYGORIAN, M. R GAGRIELIAN, E. S BALAYAN, B. H |
| description | In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%-50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately. |
| doi_str_mv | 10.1007/BF01744604 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73453576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73453576</sourcerecordid><originalsourceid>FETCH-LOGICAL-c226t-a20bf41b46f1b7e560e065bf925f8d4b6583def39114450df9df063a44995f203</originalsourceid><addsrcrecordid>eNpFkDtLBDEURoMouj4aeyGFWAijyUweM6WKq4Jgo_WQSW7cyLxMsgvb-dPNsKvb5ML9DofcD6FzSm4oIfL2fk6oZEwQtodmVFCe5VwW-2hGKkqyssjlEToO4YsQyitaHaJDykrJuJyhn5d-BSG6TxXd0OPB4rgAbGCE3kCvYdoslp3qceeMaQFr8NB41WLlI_g11kMfvdLRpWwaKxfXOJkmzegh_EmSQaWdH4Ju0xudxqOKenGKDqxqA5xt5wn6mD--Pzxnr29PLw93r5nOcxEzlZPGMtowYWkjgQsCRPDGVjm3pWGN4GVhwBYVpYxxYmxlLBGFYqyquM1JcYKuNt7RD9_LdHLduaChbVUPwzLUsmC84FIk8HoD6vTX4MHWo3ed8uuaknqqu97VneCLrXXZdGB26KbflF9ucxW0aq1XvXbhH2Ml5TxhvxPpiJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73453576</pqid></control><display><type>article</type><title>Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>AKOPOV, S. E ; GRYGORIAN, M. R ; GAGRIELIAN, E. S ; BALAYAN, B. H</creator><creatorcontrib>AKOPOV, S. E ; GRYGORIAN, M. R ; GAGRIELIAN, E. S ; BALAYAN, B. H</creatorcontrib><description>In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%-50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/BF01744604</identifier><identifier>PMID: 1487457</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Biological and medical sciences ; Culture Techniques ; Epoprostenol - physiology ; Humans ; Intracranial Arteriosclerosis - physiopathology ; Ischemic Attack, Transient - physiopathology ; Medical sciences ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiopathology ; Neurology ; Vascular diseases and vascular malformations of the nervous system ; Vascular Resistance - drug effects ; Vascular Resistance - physiology ; Vasoconstriction - drug effects ; Vasoconstriction - physiology ; Vasoconstrictor Agents - pharmacology ; Vasodilation - drug effects ; Vasodilation - physiology ; Vasodilator Agents - pharmacology</subject><ispartof>Heart and vessels, 1992-12, Vol.7 (4), p.196-199</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-a20bf41b46f1b7e560e065bf925f8d4b6583def39114450df9df063a44995f203</citedby><cites>FETCH-LOGICAL-c226t-a20bf41b46f1b7e560e065bf925f8d4b6583def39114450df9df063a44995f203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4815557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1487457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AKOPOV, S. E</creatorcontrib><creatorcontrib>GRYGORIAN, M. R</creatorcontrib><creatorcontrib>GAGRIELIAN, E. S</creatorcontrib><creatorcontrib>BALAYAN, B. H</creatorcontrib><title>Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><description>In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%-50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately.</description><subject>Biological and medical sciences</subject><subject>Culture Techniques</subject><subject>Epoprostenol - physiology</subject><subject>Humans</subject><subject>Intracranial Arteriosclerosis - physiopathology</subject><subject>Ischemic Attack, Transient - physiopathology</subject><subject>Medical sciences</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiopathology</subject><subject>Neurology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - physiology</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtLBDEURoMouj4aeyGFWAijyUweM6WKq4Jgo_WQSW7cyLxMsgvb-dPNsKvb5ML9DofcD6FzSm4oIfL2fk6oZEwQtodmVFCe5VwW-2hGKkqyssjlEToO4YsQyitaHaJDykrJuJyhn5d-BSG6TxXd0OPB4rgAbGCE3kCvYdoslp3qceeMaQFr8NB41WLlI_g11kMfvdLRpWwaKxfXOJkmzegh_EmSQaWdH4Ju0xudxqOKenGKDqxqA5xt5wn6mD--Pzxnr29PLw93r5nOcxEzlZPGMtowYWkjgQsCRPDGVjm3pWGN4GVhwBYVpYxxYmxlLBGFYqyquM1JcYKuNt7RD9_LdHLduaChbVUPwzLUsmC84FIk8HoD6vTX4MHWo3ed8uuaknqqu97VneCLrXXZdGB26KbflF9ucxW0aq1XvXbhH2Ml5TxhvxPpiJg</recordid><startdate>199212</startdate><enddate>199212</enddate><creator>AKOPOV, S. E</creator><creator>GRYGORIAN, M. R</creator><creator>GAGRIELIAN, E. S</creator><creator>BALAYAN, B. H</creator><general>Springer-Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199212</creationdate><title>Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch</title><author>AKOPOV, S. E ; GRYGORIAN, M. R ; GAGRIELIAN, E. S ; BALAYAN, B. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-a20bf41b46f1b7e560e065bf925f8d4b6583def39114450df9df063a44995f203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Culture Techniques</topic><topic>Epoprostenol - physiology</topic><topic>Humans</topic><topic>Intracranial Arteriosclerosis - physiopathology</topic><topic>Ischemic Attack, Transient - physiopathology</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiopathology</topic><topic>Neurology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vascular Resistance - drug effects</topic><topic>Vascular Resistance - physiology</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - physiology</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AKOPOV, S. E</creatorcontrib><creatorcontrib>GRYGORIAN, M. R</creatorcontrib><creatorcontrib>GAGRIELIAN, E. S</creatorcontrib><creatorcontrib>BALAYAN, B. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AKOPOV, S. E</au><au>GRYGORIAN, M. R</au><au>GAGRIELIAN, E. S</au><au>BALAYAN, B. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch</atitle><jtitle>Heart and vessels</jtitle><addtitle>Heart Vessels</addtitle><date>1992-12</date><risdate>1992</risdate><volume>7</volume><issue>4</issue><spage>196</spage><epage>199</epage><pages>196-199</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%-50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately.</abstract><cop>Heidelberg</cop><cop>Tokyo</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>1487457</pmid><doi>10.1007/BF01744604</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-8327 |
| ispartof | Heart and vessels, 1992-12, Vol.7 (4), p.196-199 |
| issn | 0910-8327 1615-2573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73453576 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Culture Techniques Epoprostenol - physiology Humans Intracranial Arteriosclerosis - physiopathology Ischemic Attack, Transient - physiopathology Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Neurology Vascular diseases and vascular malformations of the nervous system Vascular Resistance - drug effects Vascular Resistance - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology |
| title | Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T21%3A03%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20the%20dependence%20of%20human%20middle%20cerebral%20artery%20contractile%20activity%20on%20the%20presence%20of%20an%20atherosclerotic%20patch&rft.jtitle=Heart%20and%20vessels&rft.au=AKOPOV,%20S.%20E&rft.date=1992-12&rft.volume=7&rft.issue=4&rft.spage=196&rft.epage=199&rft.pages=196-199&rft.issn=0910-8327&rft.eissn=1615-2573&rft.coden=HEVEEO&rft_id=info:doi/10.1007/BF01744604&rft_dat=%3Cproquest_cross%3E73453576%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73453576&rft_id=info:pmid/1487457&rfr_iscdi=true |