Gabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints

The antiepileptic drug gabapentin has been shown to have an antihyperalgesic effect following central administration. This electrophysiological investigation examined whether peripherally administered gabapentin could modulate the mechanosensitivity of primary afferents innervating normal and kaolin...

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Veröffentlicht in:	Pain (Amsterdam) 2003-07, Vol.104 (1), p.363-366
Hauptverfasser:	Hanesch, Ulrike, Pawlak, Matthias, McDougall, Jason J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Acetates - therapeutic use Amines Analgesics Animals Biological and medical sciences Cyclohexanecarboxylic Acids Dose-Response Relationship, Drug Gabapentin gamma-Aminobutyric Acid Inflammation Inflammation - drug therapy Inflammation - physiopathology Knee joint Knee Joint - drug effects Knee Joint - physiopathology Male Mechanosensitivity Mechanotransduction, Cellular - drug effects Mechanotransduction, Cellular - physiology Medical sciences Neurons, Afferent - drug effects Neurons, Afferent - physiology Neuropharmacology Pain Pharmacology. Drug treatments Rat Rats Rats, Wistar
Online-Zugang:	Volltext
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