Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

Background Components of grapefruit juice may impair the activity of intestinal cytochrome P450 (CYP) 3A enzymes, sometimes resulting in clinically important drug interactions. The time course of recovery from CYP3A inhibition after a single exposure to grapefruit juice is not clearly established. M...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2003-08, Vol.74 (2), p.121-129
Hauptverfasser:	Greenblatt, David J., Moltke, Lisa L., Harmatz, Jerold S., Chen, Gengsheng, Weemhoff, James L., Jen, Cheng, Kelley, Charles J., LeDuc, Barbara W., Zinny, Miguel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Aryl Hydrocarbon Hydroxylases - metabolism Beverages Biological and medical sciences Biotransformation Chromatography, Gas Citrus paradisi Cytochrome P-450 CYP3A Drug toxicity and drugs side effects treatment Female Furocoumarins - pharmacology Half-Life Humans Hypnotics and Sedatives - pharmacokinetics Isoenzymes - metabolism Kinetics Liver - metabolism Male Medical sciences Midazolam - pharmacokinetics Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Oxidoreductases, N-Demethylating - metabolism Pharmacology. Drug treatments Triazolam - pharmacokinetics
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