IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES
A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also repo...
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| Veröffentlicht in: | Journal of antibiotics 1992/12/25, Vol.45(12), pp.1914-1918 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
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| container_end_page | 1918 |
|---|---|
| container_issue | 12 |
| container_start_page | 1914 |
| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | SHOWALTER, H. D. HOLLIS BUNGE, RICHARD H. FRENCH, JAMES C. HURLEY, TIMOTHY R. LEEDS, ROBERT L. LEJA, BOGUSLAWA MCDONNELL, PETER D. EDMUNDS, COLIN R. |
| description | A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also reported. |
| doi_str_mv | 10.7164/antibiotics.45.1914 |
| format | Article |
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D. HOLLIS ; BUNGE, RICHARD H. ; FRENCH, JAMES C. ; HURLEY, TIMOTHY R. ; LEEDS, ROBERT L. ; LEJA, BOGUSLAWA ; MCDONNELL, PETER D. ; EDMUNDS, COLIN R.</creator><creatorcontrib>SHOWALTER, H. D. HOLLIS ; BUNGE, RICHARD H. ; FRENCH, JAMES C. ; HURLEY, TIMOTHY R. ; LEEDS, ROBERT L. ; LEJA, BOGUSLAWA ; MCDONNELL, PETER D. ; EDMUNDS, COLIN R.</creatorcontrib><description>A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also reported.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.1914</identifier><identifier>PMID: 1490883</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Chromatography, Ion Exchange ; Deoxyguanosine - chemistry ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Glycerolipids, phospholipids ; Lipids ; Magnetic Resonance Spectroscopy ; Other biological molecules ; Pentostatin - chemistry ; Pentostatin - isolation & purification ; Streptomyces antibioticus - chemistry</subject><ispartof>The Journal of Antibiotics, 1992/12/25, Vol.45(12), pp.1914-1918</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-56284810e3367ae26688383c43ee3419bddab0db64d309660d28f0c850a99033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4745592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1490883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHOWALTER, H. D. HOLLIS</creatorcontrib><creatorcontrib>BUNGE, RICHARD H.</creatorcontrib><creatorcontrib>FRENCH, JAMES C.</creatorcontrib><creatorcontrib>HURLEY, TIMOTHY R.</creatorcontrib><creatorcontrib>LEEDS, ROBERT L.</creatorcontrib><creatorcontrib>LEJA, BOGUSLAWA</creatorcontrib><creatorcontrib>MCDONNELL, PETER D.</creatorcontrib><creatorcontrib>EDMUNDS, COLIN R.</creatorcontrib><title>IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also reported.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Ion Exchange</subject><subject>Deoxyguanosine - chemistry</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycerolipids, phospholipids</subject><subject>Lipids</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Other biological molecules</subject><subject>Pentostatin - chemistry</subject><subject>Pentostatin - isolation & purification</subject><subject>Streptomyces antibioticus - chemistry</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9PgzAUxRujmXP6CYwJD8Y3ZktLaR_nACXZYNnQ16aUTjHsj5Q9-O3tZM699Kb3_O49NweAWwSHAaLkUa7bqqg2baXMkPhDxBE5A33EGHIRofwc9CH0kMuYBy_BlTGfEOIAB6wHeohwyBjug0Uync2ztyh0bAlfx3mSpU4WO7MozbNFPsqT1BmloZOEtpHEyXj0R8TRfGp73X-cTaN89JRNkjxaXIOLpayNvjnUAcjjKB-_uJPs2S6YuIoS1ro-9RhhCGqMaSC1R6m9iGFFsNaYIF6UpSxgWVBSYsgphaXHllAxH0rOIcYD8NCt3Tabr502rVhVRum6lmu92RkRYOJ7hFAL4g5UzcaYRi_FtqlWsvkWCIp9kuIkSUF8sU_STt0d1u-KlS7_Z7rorH5_0KVRsl42cq0qc8RIQHyfexZLO-zTtPJdH3XZWLdan1ojTtmvvXd493ccQfUhG6HX-AcKEJKx</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>SHOWALTER, H. D. HOLLIS</creator><creator>BUNGE, RICHARD H.</creator><creator>FRENCH, JAMES C.</creator><creator>HURLEY, TIMOTHY R.</creator><creator>LEEDS, ROBERT L.</creator><creator>LEJA, BOGUSLAWA</creator><creator>MCDONNELL, PETER D.</creator><creator>EDMUNDS, COLIN R.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES</title><author>SHOWALTER, H. D. HOLLIS ; BUNGE, RICHARD H. ; FRENCH, JAMES C. ; HURLEY, TIMOTHY R. ; LEEDS, ROBERT L. ; LEJA, BOGUSLAWA ; MCDONNELL, PETER D. ; EDMUNDS, COLIN R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-56284810e3367ae26688383c43ee3419bddab0db64d309660d28f0c850a99033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chromatography, Ion Exchange</topic><topic>Deoxyguanosine - chemistry</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycerolipids, phospholipids</topic><topic>Lipids</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Other biological molecules</topic><topic>Pentostatin - chemistry</topic><topic>Pentostatin - isolation & purification</topic><topic>Streptomyces antibioticus - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHOWALTER, H. D. HOLLIS</creatorcontrib><creatorcontrib>BUNGE, RICHARD H.</creatorcontrib><creatorcontrib>FRENCH, JAMES C.</creatorcontrib><creatorcontrib>HURLEY, TIMOTHY R.</creatorcontrib><creatorcontrib>LEEDS, ROBERT L.</creatorcontrib><creatorcontrib>LEJA, BOGUSLAWA</creatorcontrib><creatorcontrib>MCDONNELL, PETER D.</creatorcontrib><creatorcontrib>EDMUNDS, COLIN R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHOWALTER, H. D. HOLLIS</au><au>BUNGE, RICHARD H.</au><au>FRENCH, JAMES C.</au><au>HURLEY, TIMOTHY R.</au><au>LEEDS, ROBERT L.</au><au>LEJA, BOGUSLAWA</au><au>MCDONNELL, PETER D.</au><au>EDMUNDS, COLIN R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>12</issue><spage>1914</spage><epage>1918</epage><pages>1914-1918</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1992/12/25, Vol.45(12), pp.1914-1918 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73452446 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid Chromatography, Ion Exchange Deoxyguanosine - chemistry Fermentation Fundamental and applied biological sciences. Psychology Glycerolipids, phospholipids Lipids Magnetic Resonance Spectroscopy Other biological molecules Pentostatin - chemistry Pentostatin - isolation & purification Streptomyces antibioticus - chemistry |
| title | IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES |
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