IMPROVED PRODUCTION OF PENTOSTATIN AND IDENTIFICATION OF FERMENTATION COMETABOLITES

A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also repo...

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Veröffentlicht in:	Journal of antibiotics 1992/12/25, Vol.45(12), pp.1914-1918
Hauptverfasser:	SHOWALTER, H. D. HOLLIS, BUNGE, RICHARD H., FRENCH, JAMES C., HURLEY, TIMOTHY R., LEEDS, ROBERT L., LEJA, BOGUSLAWA, MCDONNELL, PETER D., EDMUNDS, COLIN R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid Chromatography, Ion Exchange Deoxyguanosine - chemistry Fermentation Fundamental and applied biological sciences. Psychology Glycerolipids, phospholipids Lipids Magnetic Resonance Spectroscopy Other biological molecules Pentostatin - chemistry Pentostatin - isolation & purification Streptomyces antibioticus - chemistry
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Zusammenfassung:	A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also reported.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.1914