Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells

The Ewing family of tumors are poorly differentiated pediatric solid tumors arising in bone and soft tissues from an unknown cell of origin. Ewing tumors are molecularly defined by in-frame genomic fusions that combine EWS with one of several ETS genes, most commonly FLI-1. We considered pluripotent...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-07, Vol.63 (13), p.3464-3468
Hauptverfasser:	TORCHIA, Enrique C, JAISHANKAR, Sobha, BAKER, Suzanne J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Animals Biological and medical sciences Bone Marrow Cells - cytology Cell Differentiation - physiology Cyclin-Dependent Kinase Inhibitor p16 - deficiency Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Medical sciences Medulloblastoma - genetics Medulloblastoma - pathology Mice Mice, Knockout Oncogene Proteins - genetics Oncogene Proteins - physiology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology Pluripotent Stem Cells - cytology Polymerase Chain Reaction Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins RNA-Binding Protein EWS - deficiency RNA-Binding Protein EWS - genetics RNA-Binding Protein EWS - physiology Sarcoma, Ewing - genetics Trans-Activators - genetics Trans-Activators - physiology Transcription Factors - genetics Transcription Factors - physiology Transcriptional Regulator ERG Tumor Cells, Cultured
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