Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten
The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized, paralyzed and artificially ventilated newborn kittens aged 0–17 days. Single or few fiber preparations of chemoreceptors were made from one carotid sinus...
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| Veröffentlicht in: | Respiration physiology 1992-11, Vol.90 (2), p.173-183 |
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| creator | Marchal, F Bairam, A Haouzi, P Hascoet, J.M Crance, J.P Vert, P Lahiri, S |
| description | The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized, paralyzed and artificially ventilated newborn kittens aged 0–17 days. Single or few fiber preparations of chemoreceptors were made from one carotid sinus nerve. The responses of the chemosensory afferents to intravenous injections of dopamine (5–50 μg·kg
−1) were studied in kittens breathing air and 8% O
2 in N
2. The effects of haloperidol on the chemosensory activity in air or 100% O
2 and on the chemosensory response to hypoxia were studied. Dopamine inhibited the chemosensory discharge in
25
44
studies in normoxia. Of the 9 studies performed in hypoxia, dopamine was excitatory in 5 or had no effect in 4 (
P |
| doi_str_mv | 10.1016/0034-5687(92)90079-C |
| format | Article |
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−1) were studied in kittens breathing air and 8% O
2 in N
2. The effects of haloperidol on the chemosensory activity in air or 100% O
2 and on the chemosensory response to hypoxia were studied. Dopamine inhibited the chemosensory discharge in
25
44
studies in normoxia. Of the 9 studies performed in hypoxia, dopamine was excitatory in 5 or had no effect in 4 (
P<0.05
vs normoxia). Inhibition of the chemosensory discharge was observed in
24
37
studies performed in kittens aged more than 3 days and was predominantly excitatory in
6
7
studies in kittens aged 0–3 days (
P<0.01). One minute after haloperidol, the chemosensory discharge had increased significantly in all experiments. The biphasic pattern of chemosensory response to hypoxia (Marchal
et al., Respir. Physiol. 87: 183–193, 1992) was not changed by haloperidol. The steady-state chemosensory activity was significantly increased after haloperidol, respectively from 3.9±0.7 impulses·sec
−1 to 9.8±1.2 impulses·sec
−1 in air, and from 13.1±1.4 impulses·sec
−1 in hypoxia (mean ±
SSEM,
P<0.03). It is concluded that the dopaminergic mechanisms are active in the carotid body of the kitten, and the observed responses to dopamine and haloperidol are qualitatively similar to those reported in the adult cat.</description><identifier>ISSN: 0034-5687</identifier><identifier>DOI: 10.1016/0034-5687(92)90079-C</identifier><identifier>PMID: 1494718</identifier><identifier>CODEN: RSPYAK</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Action Potentials - drug effects ; Analysis of Variance ; Animals ; Animals, Newborn ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Carotid Body - drug effects ; Carotid chemoreceptors, dopamine ; Cats ; Control of breathing, carotid chemoreceptors ; Dopamine - administration & dosage ; Dopamine - pharmacology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Haloperidol - administration & dosage ; Haloperidol - pharmacology ; Injections, Intravenous ; Mammals, cat ; Mediators, dopamine ; Neurons, Afferent - drug effects ; Oxygen - physiology ; Pharmacological agents, dopamine receptor blocker ; Pressoreceptors - physiology ; Respiration - drug effects ; Vertebrates: respiratory system</subject><ispartof>Respiration physiology, 1992-11, Vol.90 (2), p.173-183</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d8fb19985f5f4fd8f0faaafc4170b7547a27b97c127151c67da8b0b58fc235ee3</citedby><cites>FETCH-LOGICAL-c386t-d8fb19985f5f4fd8f0faaafc4170b7547a27b97c127151c67da8b0b58fc235ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4672909$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1494718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchal, F</creatorcontrib><creatorcontrib>Bairam, A</creatorcontrib><creatorcontrib>Haouzi, P</creatorcontrib><creatorcontrib>Hascoet, J.M</creatorcontrib><creatorcontrib>Crance, J.P</creatorcontrib><creatorcontrib>Vert, P</creatorcontrib><creatorcontrib>Lahiri, S</creatorcontrib><title>Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten</title><title>Respiration physiology</title><addtitle>Respir Physiol</addtitle><description>The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized, paralyzed and artificially ventilated newborn kittens aged 0–17 days. Single or few fiber preparations of chemoreceptors were made from one carotid sinus nerve. The responses of the chemosensory afferents to intravenous injections of dopamine (5–50 μg·kg
−1) were studied in kittens breathing air and 8% O
2 in N
2. The effects of haloperidol on the chemosensory activity in air or 100% O
2 and on the chemosensory response to hypoxia were studied. Dopamine inhibited the chemosensory discharge in
25
44
studies in normoxia. Of the 9 studies performed in hypoxia, dopamine was excitatory in 5 or had no effect in 4 (
P<0.05
vs normoxia). Inhibition of the chemosensory discharge was observed in
24
37
studies performed in kittens aged more than 3 days and was predominantly excitatory in
6
7
studies in kittens aged 0–3 days (
P<0.01). One minute after haloperidol, the chemosensory discharge had increased significantly in all experiments. The biphasic pattern of chemosensory response to hypoxia (Marchal
et al., Respir. Physiol. 87: 183–193, 1992) was not changed by haloperidol. The steady-state chemosensory activity was significantly increased after haloperidol, respectively from 3.9±0.7 impulses·sec
−1 to 9.8±1.2 impulses·sec
−1 in air, and from 13.1±1.4 impulses·sec
−1 in hypoxia (mean ±
SSEM,
P<0.03). It is concluded that the dopaminergic mechanisms are active in the carotid body of the kitten, and the observed responses to dopamine and haloperidol are qualitatively similar to those reported in the adult cat.</description><subject>Action Potentials - drug effects</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Carotid Body - drug effects</subject><subject>Carotid chemoreceptors, dopamine</subject><subject>Cats</subject><subject>Control of breathing, carotid chemoreceptors</subject><subject>Dopamine - administration & dosage</subject><subject>Dopamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haloperidol - administration & dosage</subject><subject>Haloperidol - pharmacology</subject><subject>Injections, Intravenous</subject><subject>Mammals, cat</subject><subject>Mediators, dopamine</subject><subject>Neurons, Afferent - drug effects</subject><subject>Oxygen - physiology</subject><subject>Pharmacological agents, dopamine receptor blocker</subject><subject>Pressoreceptors - physiology</subject><subject>Respiration - drug effects</subject><subject>Vertebrates: respiratory system</subject><issn>0034-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhnVIcFI3b9CADqEkh02lXe1qdSkEt2kDhkJpz0KrHWElu5KjkRv89lnHxr3lNMz83wzDR8gnzm45480XxipR1E0rr1V5oxiTqlickPPj-Ix8QHxkU9-wZkZmXCgheXtOfn_bmIEmwHUMCEijo9akmH1P7QrGiBAwpi01zkGCkJHmSPu4NqMPQH2geQU0wEsXU6BPPmcIH8mpMwPCxaHOyd_7738WP4vlrx8Pi7tlYau2yUXfuo4r1daudsJNHXPGGGcFl6yTtZCmlJ2SlpeS19w2sjdtx7q6dbasaoBqTj7v765TfN4AZj16tDAMJkDcoJaVEIrXbALFHrQpIiZwep38aNJWc6Z3-vTOk9550qrUb_r0Ylq7PNzfdCP0_5f27qb86pAbtGZwyQTr8YiJRpaKqQn7usdgcvHPQ9JoPQQLvU9gs-6jf_-PV3epjug</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Marchal, F</creator><creator>Bairam, A</creator><creator>Haouzi, P</creator><creator>Hascoet, J.M</creator><creator>Crance, J.P</creator><creator>Vert, P</creator><creator>Lahiri, S</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten</title><author>Marchal, F ; Bairam, A ; Haouzi, P ; Hascoet, J.M ; Crance, J.P ; Vert, P ; Lahiri, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d8fb19985f5f4fd8f0faaafc4170b7547a27b97c127151c67da8b0b58fc235ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Action Potentials - drug effects</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Carotid Body - drug effects</topic><topic>Carotid chemoreceptors, dopamine</topic><topic>Cats</topic><topic>Control of breathing, carotid chemoreceptors</topic><topic>Dopamine - administration & dosage</topic><topic>Dopamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haloperidol - administration & dosage</topic><topic>Haloperidol - pharmacology</topic><topic>Injections, Intravenous</topic><topic>Mammals, cat</topic><topic>Mediators, dopamine</topic><topic>Neurons, Afferent - drug effects</topic><topic>Oxygen - physiology</topic><topic>Pharmacological agents, dopamine receptor blocker</topic><topic>Pressoreceptors - physiology</topic><topic>Respiration - drug effects</topic><topic>Vertebrates: respiratory system</topic><toplevel>online_resources</toplevel><creatorcontrib>Marchal, F</creatorcontrib><creatorcontrib>Bairam, A</creatorcontrib><creatorcontrib>Haouzi, P</creatorcontrib><creatorcontrib>Hascoet, J.M</creatorcontrib><creatorcontrib>Crance, J.P</creatorcontrib><creatorcontrib>Vert, P</creatorcontrib><creatorcontrib>Lahiri, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchal, F</au><au>Bairam, A</au><au>Haouzi, P</au><au>Hascoet, J.M</au><au>Crance, J.P</au><au>Vert, P</au><au>Lahiri, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten</atitle><jtitle>Respiration physiology</jtitle><addtitle>Respir Physiol</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>90</volume><issue>2</issue><spage>173</spage><epage>183</epage><pages>173-183</pages><issn>0034-5687</issn><coden>RSPYAK</coden><abstract>The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized, paralyzed and artificially ventilated newborn kittens aged 0–17 days. Single or few fiber preparations of chemoreceptors were made from one carotid sinus nerve. The responses of the chemosensory afferents to intravenous injections of dopamine (5–50 μg·kg
−1) were studied in kittens breathing air and 8% O
2 in N
2. The effects of haloperidol on the chemosensory activity in air or 100% O
2 and on the chemosensory response to hypoxia were studied. Dopamine inhibited the chemosensory discharge in
25
44
studies in normoxia. Of the 9 studies performed in hypoxia, dopamine was excitatory in 5 or had no effect in 4 (
P<0.05
vs normoxia). Inhibition of the chemosensory discharge was observed in
24
37
studies performed in kittens aged more than 3 days and was predominantly excitatory in
6
7
studies in kittens aged 0–3 days (
P<0.01). One minute after haloperidol, the chemosensory discharge had increased significantly in all experiments. The biphasic pattern of chemosensory response to hypoxia (Marchal
et al., Respir. Physiol. 87: 183–193, 1992) was not changed by haloperidol. The steady-state chemosensory activity was significantly increased after haloperidol, respectively from 3.9±0.7 impulses·sec
−1 to 9.8±1.2 impulses·sec
−1 in air, and from 13.1±1.4 impulses·sec
−1 in hypoxia (mean ±
SSEM,
P<0.03). It is concluded that the dopaminergic mechanisms are active in the carotid body of the kitten, and the observed responses to dopamine and haloperidol are qualitatively similar to those reported in the adult cat.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1494718</pmid><doi>10.1016/0034-5687(92)90079-C</doi><tpages>11</tpages></addata></record> |
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| ispartof | Respiration physiology, 1992-11, Vol.90 (2), p.173-183 |
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| language | eng |
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| subjects | Action Potentials - drug effects Analysis of Variance Animals Animals, Newborn Biological and medical sciences Blood Pressure - drug effects Cardiorespiratory control. Arterial mecano- and chemoreceptor Carotid Body - drug effects Carotid chemoreceptors, dopamine Cats Control of breathing, carotid chemoreceptors Dopamine - administration & dosage Dopamine - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Haloperidol - administration & dosage Haloperidol - pharmacology Injections, Intravenous Mammals, cat Mediators, dopamine Neurons, Afferent - drug effects Oxygen - physiology Pharmacological agents, dopamine receptor blocker Pressoreceptors - physiology Respiration - drug effects Vertebrates: respiratory system |
| title | Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten |
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