Significance of the Melanocortin 1 Receptor in Regulating Human Melanocyte Pigmentation, Proliferation, and Survival

: The characterization of the melanocortin 1 receptor (MC1R) expressed on human melanocytes and the findings that certain mutations in the POMC gene or the MC1R gene result in red hair phenotype underscore the significance of melanocortins and MC1R in regulating human pigmentation. We demonstrated t...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-06, Vol.994 (1), p.359-365
Hauptverfasser:	KADEKARO, ANA LUISA, KANTO, HIROMI, KAVANAGH, RENNY, ABDEL-MALEK, ZALFA A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti Signaling Protein alpha-MSH - metabolism Animals Cell Survival - physiology Humans Intercellular Signaling Peptides and Proteins melanocortin 1 receptor melanocortins melanocytes Melanocytes - physiology Melanocytes - radiation effects melanoma pigmentation Pigmentation - physiology Proteins - metabolism Receptors, Corticotropin - genetics Receptors, Corticotropin - metabolism Receptors, Melanocortin Risk Factors skin cancer Skin Neoplasms - metabolism ultraviolet radiation Ultraviolet Rays
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