Pharmacological, pharmacokinetic and clinical profile of eletriptan (Relpax®), a new triptan for migraine

Eletriptan (Relpax®) is a new anti-migraine medication commonly referred to as triptans. Eletriptan is considered to reduce neuronal transmission of pain by causing vasoconstriction of dilated cranial vessels and inhibiting the release of neuropeptides from trigeminal nerves via activation of the 5-...

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Veröffentlicht in:	Folia Pharmacologica Japonica 2003, Vol.122(1), pp.93-101
1. Verfasser:	OMOTE, Masayuki
Format:	Artikel
Sprache:	jpn
Schlagworte:	5-HT1B/1D receptor agonist Administration, Oral Animals Capillary Permeability - drug effects cranial vessel eletriptan Humans Indoles - administration & dosage Indoles - pharmacokinetics Indoles - pharmacology migraine Migraine Disorders - drug therapy Pyrrolidines - administration & dosage Pyrrolidines - pharmacokinetics Pyrrolidines - pharmacology Receptor, Serotonin, 5-HT1B Receptors, Serotonin - metabolism Serotonin Receptor Agonists - pharmacokinetics Serotonin Receptor Agonists - pharmacology Serotonin Receptor Agonists - therapeutic use Skull - blood supply trigeminal nerve Trigeminal Nerve - physiology Tryptamines Vasoconstriction - drug effects
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