Regulation of HDM2 activity by the ribosomal protein L11

The HDM2 protein plays an important role in regulating the stability and function of the p53 tumor suppressor protein. In this report, we show that the ribosomal protein L11 can interact with HDM2 and inhibit HDM2 function, thus leading to the stabilization and activation of p53. The inhibition of H...

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Veröffentlicht in:	Cancer cell 2003-06, Vol.3 (6), p.577-587
Hauptverfasser:	Lohrum, Marion A.E, Ludwig, Robert L, Kubbutat, Michael H.G, Hanlon, Mary, Vousden, Karen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - drug effects Cells, Cultured Dactinomycin - pharmacology Fibroblasts - metabolism Gene Expression Regulation Humans Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins Plasmids Protein Biosynthesis Protein Synthesis Inhibitors - pharmacology Protein Transport Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Ribosomal Proteins - metabolism Saccharomyces cerevisiae Subcellular Fractions Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Two-Hybrid System Techniques
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