Ultraviolet-B-Induced Oxidative DNA Base Damage in Primary Normal Human Epidermal Keratinocytes and Inhibition by a Hydroxyl Radical Scavenger

To evaluate the effects of ultraviolet-induced environmental trauma on human skin cells, primary normal human epidermal keratinocytes were exposed to ultraviolet-B radiation (290–320 nm). We found that relatively low doses of ultraviolet-B (62.5–500 mJ per cm2) caused dose-dependent increases in 8-o...

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