Naftopidil, a new adrenoceptor blocking agent with Ca(2+)-antagonistic properties: interaction with adrenoceptors

The interaction of naftopidil with adrenoceptors was studied in comparison to standard drugs. Naftopidil binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil to alpha 2- and beta-adrenocepto...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1992-12, Vol.20 (6), p.1006-1013
Hauptverfasser:	Sponer, G, Borbe, H O, Müller-Beckmann, B, Freud, P, Jakob, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - metabolism Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Binding, Competitive - drug effects Blood Pressure - drug effects Calcium Channel Blockers - metabolism Calcium Channel Blockers - pharmacology Decerebrate State - physiopathology In Vitro Techniques Male Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Naphthalenes - metabolism Naphthalenes - pharmacology Norepinephrine - pharmacology Piperazines - metabolism Piperazines - pharmacology Propranolol - pharmacology Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Adrenergic - drug effects Receptors, Adrenergic - metabolism Vasodilation - drug effects
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