Nitric oxide mediated formation of cyclic GMP in the olfactory system
OLFACTORY cilia preparation from rats contain considerable activity of soluble guanylate cyclase as indicated by the formation of cyclic GMP (cGMP) upon application of nitroprusside, a nitric oxide generating agent. Stimulation of olfactory cilia with high doses of odorants elicited a delayed and su...
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| Veröffentlicht in: | Neuroreport 1992-11, Vol.3 (11), p.1030-1030 |
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| container_title | Neuroreport |
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| creator | Breer, Heinz Klemm, Thomas Boekhoff, Ingrid |
| description | OLFACTORY cilia preparation from rats contain considerable activity of soluble guanylate cyclase as indicated by the formation of cyclic GMP (cGMP) upon application of nitroprusside, a nitric oxide generating agent. Stimulation of olfactory cilia with high doses of odorants elicited a delayed and sustained elevation of the cGMP-concentration. The odorant-induced cGMP-response was abolished by L-N-nitro-arginine, a selective inhibitor of nitric oxide synthesis, as well as by haemoglobin which efficiently binds and inactivates nitric oxide. These observations suggest that the NO/cGMP cascade may plan an important role in signal processing of the olfactory system. |
| doi_str_mv | 10.1097/00001756-199211000-00022 |
| format | Article |
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Stimulation of olfactory cilia with high doses of odorants elicited a delayed and sustained elevation of the cGMP-concentration. The odorant-induced cGMP-response was abolished by L-N-nitro-arginine, a selective inhibitor of nitric oxide synthesis, as well as by haemoglobin which efficiently binds and inactivates nitric oxide. These observations suggest that the NO/cGMP cascade may plan an important role in signal processing of the olfactory system.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199211000-00022</identifier><identifier>PMID: 1362359</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Biological and medical sciences ; Cilia - metabolism ; Cyclic AMP - metabolism ; Cyclic GMP - metabolism ; Fundamental and applied biological sciences. Psychology ; Guanylate Cyclase - metabolism ; Hemoglobins - metabolism ; In Vitro Techniques ; Nitric Oxide - metabolism ; Nitroarginine ; Nitroprusside - pharmacology ; Odorants ; Olfactory Mucosa - metabolism ; Olfactory system and olfaction. 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Stimulation of olfactory cilia with high doses of odorants elicited a delayed and sustained elevation of the cGMP-concentration. The odorant-induced cGMP-response was abolished by L-N-nitro-arginine, a selective inhibitor of nitric oxide synthesis, as well as by haemoglobin which efficiently binds and inactivates nitric oxide. These observations suggest that the NO/cGMP cascade may plan an important role in signal processing of the olfactory system.</description><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cilia - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic GMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate Cyclase - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>In Vitro Techniques</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitroarginine</subject><subject>Nitroprusside - pharmacology</subject><subject>Odorants</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtrXCEQgKW0pJu0P6HgQ-nbSRwvR30sITdI0j40kDdxPcraetZUXZL99zXdbfpUKgwi8804fIMQBnIMRMsT0g9IMQ6gNQXor6EHpa_QArhkgxDq_jVaEC30wPUo3qLDWr93RBNQB-gA2EiZ0At0dhtbiQ7npzh5PPsp2uYnHHKZbYt5jXPAbutSRy5uvuK4xm3lcU7BupbLFtdtbX5-h94Em6p_v7-P0N352bfTy-H6y8XV6efrwXEFdHCOL7X0kigtqRRuYk44SrWf7EioIlQ4CMugtIM-HUAQklFPeKBBg5IjO0Kfdn0fSv658bWZOVbnU7JrnzfVSMY5lyP5LwgjY1Ry1UG1A13JtRYfzEOJsy1bA8Q8qzZ_VJsX1ea36l76Yf_HZtnF_S3cue35j_u8rc6mUOzaxfqCca6FhOdR-Q57zKn5Un-kzaMvZuVtaivzr0WzXw--k58</recordid><startdate>199211</startdate><enddate>199211</enddate><creator>Breer, Heinz</creator><creator>Klemm, Thomas</creator><creator>Boekhoff, Ingrid</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199211</creationdate><title>Nitric oxide mediated formation of cyclic GMP in the olfactory system</title><author>Breer, Heinz ; Klemm, Thomas ; Boekhoff, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4812-cc4b97e70897275cd3c5c229eda6028025c1fbf89c123511f5732e04f2f918763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cilia - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanylate Cyclase - metabolism</topic><topic>Hemoglobins - metabolism</topic><topic>In Vitro Techniques</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitroarginine</topic><topic>Nitroprusside - pharmacology</topic><topic>Odorants</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breer, Heinz</creatorcontrib><creatorcontrib>Klemm, Thomas</creatorcontrib><creatorcontrib>Boekhoff, Ingrid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breer, Heinz</au><au>Klemm, Thomas</au><au>Boekhoff, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide mediated formation of cyclic GMP in the olfactory system</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1992-11</date><risdate>1992</risdate><volume>3</volume><issue>11</issue><spage>1030</spage><epage>1030</epage><pages>1030-1030</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>OLFACTORY cilia preparation from rats contain considerable activity of soluble guanylate cyclase as indicated by the formation of cyclic GMP (cGMP) upon application of nitroprusside, a nitric oxide generating agent. Stimulation of olfactory cilia with high doses of odorants elicited a delayed and sustained elevation of the cGMP-concentration. The odorant-induced cGMP-response was abolished by L-N-nitro-arginine, a selective inhibitor of nitric oxide synthesis, as well as by haemoglobin which efficiently binds and inactivates nitric oxide. These observations suggest that the NO/cGMP cascade may plan an important role in signal processing of the olfactory system.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1362359</pmid><doi>10.1097/00001756-199211000-00022</doi><tpages>1</tpages></addata></record> |
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| ispartof | Neuroreport, 1992-11, Vol.3 (11), p.1030-1030 |
| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Cilia - metabolism Cyclic AMP - metabolism Cyclic GMP - metabolism Fundamental and applied biological sciences. Psychology Guanylate Cyclase - metabolism Hemoglobins - metabolism In Vitro Techniques Nitric Oxide - metabolism Nitroarginine Nitroprusside - pharmacology Odorants Olfactory Mucosa - metabolism Olfactory system and olfaction. Gustatory system and gustation Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs |
| title | Nitric oxide mediated formation of cyclic GMP in the olfactory system |
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