Determination of β‐carotene in plasma, blood cells and buccal mucosa by electrochemical detection
The β‐carotene concentrations in plasma, blood cells and buccal mucosal cells were determined by high‐performance liquid chromatography with electrochemical detection. This method was 1,000 times more sensitive than the conventional spectrophotometric method. Polymorphonuclear cells and red blood ce...
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| Veröffentlicht in: | Lipids 1992-11, Vol.27 (11), p.840-843 |
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| container_end_page | 843 |
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| container_issue | 11 |
| container_start_page | 840 |
| container_title | Lipids |
| container_volume | 27 |
| creator | Murata, Takuji Tamai, Hiroshi Morinobu, Takao Manago, Mitsuhiro Takenaka, Akira Takenaka, Hiroyuki Mino, Makoto |
| description | The β‐carotene concentrations in plasma, blood cells and buccal mucosal cells were determined by high‐performance liquid chromatography with electrochemical detection. This method was 1,000 times more sensitive than the conventional spectrophotometric method. Polymorphonuclear cells and red blood cells had lower β‐carotene levels than the other cells. After oral administration of 580 mg/day of all‐trans β‐carotene to human male volunteers for a week, the β‐carotene concentrations in all cell types increased at least several times above the original levels. |
| doi_str_mv | 10.1007/BF02535860 |
| format | Article |
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This method was 1,000 times more sensitive than the conventional spectrophotometric method. Polymorphonuclear cells and red blood cells had lower β‐carotene levels than the other cells. After oral administration of 580 mg/day of all‐trans β‐carotene to human male volunteers for a week, the β‐carotene concentrations in all cell types increased at least several times above the original levels.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/BF02535860</identifier><identifier>PMID: 1491599</identifier><identifier>CODEN: LPDSAP</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Adult ; Analytical, structural and metabolic biochemistry ; beta Carotene ; Biological and medical sciences ; Blood Platelets - chemistry ; Carotenoids - analysis ; Carotenoids - blood ; Carotenoids - pharmacokinetics ; Cheek ; Chromatography, High Pressure Liquid - methods ; Electrochemistry ; Erythrocytes - chemistry ; Fundamental and applied biological sciences. Psychology ; Humans ; Leukocytes, Mononuclear - chemistry ; Male ; Mouth Mucosa - chemistry ; Neutrophils - chemistry ; Other biological molecules ; Terpenes, steroids. 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This method was 1,000 times more sensitive than the conventional spectrophotometric method. Polymorphonuclear cells and red blood cells had lower β‐carotene levels than the other cells. After oral administration of 580 mg/day of all‐trans β‐carotene to human male volunteers for a week, the β‐carotene concentrations in all cell types increased at least several times above the original levels.</description><subject>Adult</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>beta Carotene</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - chemistry</subject><subject>Carotenoids - analysis</subject><subject>Carotenoids - blood</subject><subject>Carotenoids - pharmacokinetics</subject><subject>Cheek</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Electrochemistry</subject><subject>Erythrocytes - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - chemistry</subject><subject>Male</subject><subject>Mouth Mucosa - chemistry</subject><subject>Neutrophils - chemistry</subject><subject>Other biological molecules</subject><subject>Terpenes, steroids. 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Psychology</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - chemistry</topic><topic>Male</topic><topic>Mouth Mucosa - chemistry</topic><topic>Neutrophils - chemistry</topic><topic>Other biological molecules</topic><topic>Terpenes, steroids. Hormones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murata, Takuji</creatorcontrib><creatorcontrib>Tamai, Hiroshi</creatorcontrib><creatorcontrib>Morinobu, Takao</creatorcontrib><creatorcontrib>Manago, Mitsuhiro</creatorcontrib><creatorcontrib>Takenaka, Akira</creatorcontrib><creatorcontrib>Takenaka, Hiroyuki</creatorcontrib><creatorcontrib>Mino, Makoto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murata, Takuji</au><au>Tamai, Hiroshi</au><au>Morinobu, Takao</au><au>Manago, Mitsuhiro</au><au>Takenaka, Akira</au><au>Takenaka, Hiroyuki</au><au>Mino, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of β‐carotene in plasma, blood cells and buccal mucosa by electrochemical detection</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1992-11</date><risdate>1992</risdate><volume>27</volume><issue>11</issue><spage>840</spage><epage>843</epage><pages>840-843</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><coden>LPDSAP</coden><abstract>The β‐carotene concentrations in plasma, blood cells and buccal mucosal cells were determined by high‐performance liquid chromatography with electrochemical detection. This method was 1,000 times more sensitive than the conventional spectrophotometric method. Polymorphonuclear cells and red blood cells had lower β‐carotene levels than the other cells. After oral administration of 580 mg/day of all‐trans β‐carotene to human male volunteers for a week, the β‐carotene concentrations in all cell types increased at least several times above the original levels.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>1491599</pmid><doi>10.1007/BF02535860</doi><tpages>4</tpages></addata></record> |
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| ispartof | Lipids, 1992-11, Vol.27 (11), p.840-843 |
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| language | eng |
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| subjects | Adult Analytical, structural and metabolic biochemistry beta Carotene Biological and medical sciences Blood Platelets - chemistry Carotenoids - analysis Carotenoids - blood Carotenoids - pharmacokinetics Cheek Chromatography, High Pressure Liquid - methods Electrochemistry Erythrocytes - chemistry Fundamental and applied biological sciences. Psychology Humans Leukocytes, Mononuclear - chemistry Male Mouth Mucosa - chemistry Neutrophils - chemistry Other biological molecules Terpenes, steroids. Hormones |
| title | Determination of β‐carotene in plasma, blood cells and buccal mucosa by electrochemical detection |
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