Evidence in Support of Signaling Endosome-Based Retrograde Survival of Sympathetic Neurons

The mechanism by which target-derived Nerve Growth Factor (NGF) signaling is propagated retrogradely, over extremely long distances, to cell bodies to support survival of neurons is unclear. Here we show that survival of sympathetic neurons supported by NGF on distal axons requires the kinase activi...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-07, Vol.39 (1), p.57-68
Hauptverfasser:	Ye, Haihong, Kuruvilla, Rejji, Zweifel, Larry S, Ginty, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Axonal Transport - physiology Brain-derived neurotrophic factor Cell Compartmentation - physiology Cell Survival Cells, Cultured Endosomes - metabolism Endosomes - ultrastructure Experiments Infections Ligands Nerve Growth Factor - metabolism Neurons Neurons - metabolism Neurons - ultrastructure Phosphorylation Plasma Rats Receptor, trkA - metabolism Signal Transduction - physiology Studies Sympathetic Nervous System - cytology Sympathetic Nervous System - metabolism
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