Characterisation of drug release from cubosomes using the pressure ultrafiltration method
Cubosomes have been proposed as a controlled release, intravenous drug delivery system. The objective of this study was to characterise cubosomes as either a therapeutically useful, controlled release delivery system, or as a burst release carrier such as submicron emulsions. The pressure ultrafiltr...
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| Veröffentlicht in: | International journal of pharmaceutics 2003-07, Vol.260 (2), p.239-247 |
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| container_title | International journal of pharmaceutics |
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| creator | Boyd, Ben J. |
| description | Cubosomes have been proposed as a controlled release, intravenous drug delivery system. The objective of this study was to characterise cubosomes as either a therapeutically useful, controlled release delivery system, or as a burst release carrier such as submicron emulsions. The pressure ultrafiltration method and equilibrium dialysis were used to elucidate the in vitro drug release mechanisms. On dilution of cubosomes, lipophilic compounds were released rapidly when studied by the pressure ultrafiltration method. This agrees with the behaviour predicted from simple diffusion from the bulk non-dispersed cubic phase. In contrast, equilibrium dialysis incorrectly indicated sustained drug release from cubosomes. This study illustrates that cubosomes should be classified as a burst release delivery system where drug is released by diffusion from the cubic phase matrix, and that pressure ultrafiltration may have benefits over dialysis methods for measurement of drug release from colloidal particle-based drug delivery systems. |
| doi_str_mv | 10.1016/S0378-5173(03)00262-X |
| format | Article |
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The objective of this study was to characterise cubosomes as either a therapeutically useful, controlled release delivery system, or as a burst release carrier such as submicron emulsions. The pressure ultrafiltration method and equilibrium dialysis were used to elucidate the in vitro drug release mechanisms. On dilution of cubosomes, lipophilic compounds were released rapidly when studied by the pressure ultrafiltration method. This agrees with the behaviour predicted from simple diffusion from the bulk non-dispersed cubic phase. In contrast, equilibrium dialysis incorrectly indicated sustained drug release from cubosomes. This study illustrates that cubosomes should be classified as a burst release delivery system where drug is released by diffusion from the cubic phase matrix, and that pressure ultrafiltration may have benefits over dialysis methods for measurement of drug release from colloidal particle-based drug delivery systems.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(03)00262-X</identifier><identifier>PMID: 12842343</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Chemistry, Pharmaceutical ; Controlled release ; Cubic phase ; Cubosome ; Diazepam - administration & dosage ; Diazepam - chemistry ; Diffusion ; Drug Carriers - chemistry ; Emulsions ; General pharmacology ; Griseofulvin - administration & dosage ; Griseofulvin - chemistry ; Injections, Intravenous ; Kinetics ; Lipophilic drug ; Medical sciences ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Propofol - administration & dosage ; Propofol - chemistry ; Rifampin - administration & dosage ; Rifampin - chemistry ; Solubility ; Ultrafiltration</subject><ispartof>International journal of pharmaceutics, 2003-07, Vol.260 (2), p.239-247</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e13e9234a1f0153dcc55a6708c065e1abc57186833ca2f8963593595640416c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037851730300262X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14938401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12842343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyd, Ben J.</creatorcontrib><title>Characterisation of drug release from cubosomes using the pressure ultrafiltration method</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Cubosomes have been proposed as a controlled release, intravenous drug delivery system. The objective of this study was to characterise cubosomes as either a therapeutically useful, controlled release delivery system, or as a burst release carrier such as submicron emulsions. The pressure ultrafiltration method and equilibrium dialysis were used to elucidate the in vitro drug release mechanisms. On dilution of cubosomes, lipophilic compounds were released rapidly when studied by the pressure ultrafiltration method. This agrees with the behaviour predicted from simple diffusion from the bulk non-dispersed cubic phase. In contrast, equilibrium dialysis incorrectly indicated sustained drug release from cubosomes. This study illustrates that cubosomes should be classified as a burst release delivery system where drug is released by diffusion from the cubic phase matrix, and that pressure ultrafiltration may have benefits over dialysis methods for measurement of drug release from colloidal particle-based drug delivery systems.</description><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Controlled release</subject><subject>Cubic phase</subject><subject>Cubosome</subject><subject>Diazepam - administration & dosage</subject><subject>Diazepam - chemistry</subject><subject>Diffusion</subject><subject>Drug Carriers - chemistry</subject><subject>Emulsions</subject><subject>General pharmacology</subject><subject>Griseofulvin - administration & dosage</subject><subject>Griseofulvin - chemistry</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Lipophilic drug</subject><subject>Medical sciences</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Propofol - administration & dosage</subject><subject>Propofol - chemistry</subject><subject>Rifampin - administration & dosage</subject><subject>Rifampin - chemistry</subject><subject>Solubility</subject><subject>Ultrafiltration</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6E5RcFD1Uk6ZJ25PI4hcseNCDnkI2nbqRtlkzreC_N_uBHoUhc3nemclDyDFnl5xxdfXMRF4kkufinIkLxlKVJq87ZMyLXCQiy9UuGf8iI3KA-MEYUykX-2TE0yJLRSbG5G26MMHYHoJD0zvfUV_TKgzvNEADBoHWwbfUDnOPvgWkA7runfYLoMsAiEMAOjR9MLVbvesJLfQLXx2Svdo0CEfbPiEvd7cv04dk9nT_OL2ZJVaUvE-ACyjjLYbXjEtRWSulUTkrLFMSuJlbmfNCFUJYk9ZFqYQsY0mVsYwrKybkbDN2GfznANjr1qGFpjEd-AF1Hr8Z43kE5Qa0wSMGqPUyuNaEb82ZXinVa6V65UuzWCul-jXmTrYLhnkL1V9q6zACp1vAoDVNHUxnHf5xWSmKjPHIXW84iDa-HASN1kFnoXIBbK8r7_455QeAbJNr</recordid><startdate>20030724</startdate><enddate>20030724</enddate><creator>Boyd, Ben J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030724</creationdate><title>Characterisation of drug release from cubosomes using the pressure ultrafiltration method</title><author>Boyd, Ben J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e13e9234a1f0153dcc55a6708c065e1abc57186833ca2f8963593595640416c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Controlled release</topic><topic>Cubic phase</topic><topic>Cubosome</topic><topic>Diazepam - administration & dosage</topic><topic>Diazepam - chemistry</topic><topic>Diffusion</topic><topic>Drug Carriers - chemistry</topic><topic>Emulsions</topic><topic>General pharmacology</topic><topic>Griseofulvin - administration & dosage</topic><topic>Griseofulvin - chemistry</topic><topic>Injections, Intravenous</topic><topic>Kinetics</topic><topic>Lipophilic drug</topic><topic>Medical sciences</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Propofol - administration & dosage</topic><topic>Propofol - chemistry</topic><topic>Rifampin - administration & dosage</topic><topic>Rifampin - chemistry</topic><topic>Solubility</topic><topic>Ultrafiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyd, Ben J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyd, Ben J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterisation of drug release from cubosomes using the pressure ultrafiltration method</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2003-07-24</date><risdate>2003</risdate><volume>260</volume><issue>2</issue><spage>239</spage><epage>247</epage><pages>239-247</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Cubosomes have been proposed as a controlled release, intravenous drug delivery system. The objective of this study was to characterise cubosomes as either a therapeutically useful, controlled release delivery system, or as a burst release carrier such as submicron emulsions. The pressure ultrafiltration method and equilibrium dialysis were used to elucidate the in vitro drug release mechanisms. On dilution of cubosomes, lipophilic compounds were released rapidly when studied by the pressure ultrafiltration method. This agrees with the behaviour predicted from simple diffusion from the bulk non-dispersed cubic phase. In contrast, equilibrium dialysis incorrectly indicated sustained drug release from cubosomes. This study illustrates that cubosomes should be classified as a burst release delivery system where drug is released by diffusion from the cubic phase matrix, and that pressure ultrafiltration may have benefits over dialysis methods for measurement of drug release from colloidal particle-based drug delivery systems.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12842343</pmid><doi>10.1016/S0378-5173(03)00262-X</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2003-07, Vol.260 (2), p.239-247 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Chemistry, Pharmaceutical Controlled release Cubic phase Cubosome Diazepam - administration & dosage Diazepam - chemistry Diffusion Drug Carriers - chemistry Emulsions General pharmacology Griseofulvin - administration & dosage Griseofulvin - chemistry Injections, Intravenous Kinetics Lipophilic drug Medical sciences Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Propofol - administration & dosage Propofol - chemistry Rifampin - administration & dosage Rifampin - chemistry Solubility Ultrafiltration |
| title | Characterisation of drug release from cubosomes using the pressure ultrafiltration method |
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