Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication

Ditercalinium chloride was originally synthesized for use as an anticancer drug and was then found to deplete mitochondrial DNA. Ethidium bromide is widely used to deplete mitochondrial DNA and produce mitochondrial DNA-less cell lines. Although ethidium bromide is used in the case of human cell lin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current genetics 2003-08, Vol.43 (5), p.364-370
Hauptverfasser:	Okamaoto, Mayumi, Ohsato, Takashi, Nakada, Kazuto, Isobe, Kotoyo, Spelbrink, Johannes N, Hayashi, Jun-Ichi, Hamasaki, Naotaka, Kang, Dongchon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Southern Cancer Carbazoles - metabolism Cells, Cultured Deoxyribonucleic acid DNA DNA Helicases DNA Polymerase gamma DNA Primase - metabolism DNA Replication - genetics DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism DNA-Directed DNA Polymerase - metabolism Ethidium - metabolism Genes HeLa Cells Humans Mice Microscopy, Fluorescence Mitochondrial DNA Mitochondrial Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!